Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …

Recent studies have profiled the innate immune signatures in patients infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suggest that cellular …

RIG‐I is our first line of defense against RNA viruses, serving as a pattern recognition
receptor that identifies molecular features common among dsRNA and ssRNA viral …

Human cells respond to infection by SARS-CoV-2, the virus that causes COVID-19, by
producing cytokines including type I and III interferons (IFNs) and proinflammatory factors …

The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-
2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA …

Cells have evolved highly specialized sentinels that detect viral infection and elicit an
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …

The interferon (IFN) response, a major vertebrate defense mechanism against viral
infections, is initiated by RIG-I-like receptor (RLR)-mediated recognition of viral replicative …

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), which are pivotal sensors of
RNA virus invasions, mediate the transcriptional induction of genes encoding type I …

RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune
responses and have immense physiological importance. In this review, we first summarize …