Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes
Genetically engineered mouse models are commonly preferred for studying the human
disease due to genetic and pathophysiological similarities between mice and humans. In …
disease due to genetic and pathophysiological similarities between mice and humans. In …
Sox2/Oct4: A delicately balanced partnership in pluripotent stem cells and embryogenesis
A Rizzino, EL Wuebben - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Considerable progress has been made in understanding the roles of Sox2 and Oct4 in
embryonic stem cells and mammalian embryogenesis. Specifically, significant progress has …
embryonic stem cells and mammalian embryogenesis. Specifically, significant progress has …
Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development
SD Kasowitz, J Ma, SJ Anderson, NA Leu, Y Xu… - PLoS …, 2018 - journals.plos.org
The N 6-methyladenosine (m6A) modification is the most prevalent internal RNA
modification in eukaryotes. The majority of m6A sites are found in the last exon and 3'UTRs …
modification in eukaryotes. The majority of m6A sites are found in the last exon and 3'UTRs …
Hydraulic control of mammalian embryo size and cell fate
Size control is fundamental in tissue development and homeostasis,. Although the role of
cell proliferation in these processes has been widely studied, the mechanisms that control …
cell proliferation in these processes has been widely studied, the mechanisms that control …
The RNA m6A reader YTHDF2 is essential for the post-transcriptional regulation of the maternal transcriptome and oocyte competence
YTHDF2 binds and destabilizes N 6-methyladenosine (m 6 A)-modified mRNA. The extent to
which this branch of m 6 A RNA-regulatory pathway functions in vivo and contributes to …
which this branch of m 6 A RNA-regulatory pathway functions in vivo and contributes to …
[PDF][PDF] NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
A Wree, A Eguchi, MD McGeough, CA Pena… - …, 2014 - Wiley Online Library
Inflammasome activation plays a central role in the development of drug‐induced and
obesity‐associated liver disease. However, the sources and mechanisms of inflammasome …
obesity‐associated liver disease. However, the sources and mechanisms of inflammasome …
Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1
Postnatal growth of mammalian oocytes is accompanied by a progressive gain of DNA
methylation, which is predominantly mediated by DNMT3A, a de novo DNA …
methylation, which is predominantly mediated by DNMT3A, a de novo DNA …
Asymmetric division of contractile domains couples cell positioning and fate specification
During pre-implantation development, the mammalian embryo self-organizes into the
blastocyst, which consists of an epithelial layer encapsulating the inner-cell mass (ICM) …
blastocyst, which consists of an epithelial layer encapsulating the inner-cell mass (ICM) …
NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing
K Shirane, F Miura, T Ito, MC Lorincz - Nature genetics, 2020 - nature.com
De novo DNA methylation (DNAme) in mammalian germ cells is dependent on DNMT3A
and DNMT3L. However, oocytes and spermatozoa show distinct patterns of DNAme. In …
and DNMT3L. However, oocytes and spermatozoa show distinct patterns of DNAme. In …
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
Sperm and eggs carry distinctive epigenetic modifications that are adjusted by
reprogramming after fertilization. The paternal genome in a zygote undergoes active DNA …
reprogramming after fertilization. The paternal genome in a zygote undergoes active DNA …