Chemotherapy modulates the anti-tumor immune response and outcomes depend on the
balance of favorable and unfavorable effects of drugs on anti-tumor immunity. 5-Florouracil …

5-Fluorouracil (5-FU) is one of the most widely used chemotherapeutics for the treatment of
cancers associated with the aerodigestive tract, breast, and colorectal system. The efficacy …

5-Fluorouracil (5-FU) is a chemotherapy drug widely used to treat a range of cancer types,
despite the recurrence of adverse reactions. Therefore, information on its side effects when …

The association between kidney disease and cancer is multifaceted and complex. Persons
with chronic kidney disease (CKD) have an increased incidence of cancer, and both cancer …

With the consumption of chemotherapy agents, residues of anticancer drugs may be
increasingly found in hospital and municipal wastewaters. Quantification of these highly …

This comprehensive review discusses the dosing strategies of cancer treatment drugs for
patients with impaired kidney function, specifically those with chronic kidney disease (CKD) …

Hyperammonemia plays a key role in the pathophysiology of hepatic encephalopathy (HE)
and most HE treatments are ammonia-lowering drugs. However, the usefulness of …

Purpose Fluoropyrimidines are anticancer drugs and can cause hyperammonemia both
intravenously and orally. Renal dysfunction may interact with fluoropyrimidine to cause …

The adult endocrinologist may be asked to consult on a patient for unexplained biochemical
disturbances that could be caused by an underlying inborn error of metabolism. A genetic …

Purpose Hyperammonemia is a serious adverse effect of 5-fluorouracil (5FU) administration.
Hemodialysis can be used for its management, but detailed data on the concentrations and …