Atopic dermatitis is a common chronic/chronically relapsing inflammatory skin disease, with
increasing worldwide prevalence. Etiopathogenesis is complex and multifactorial, with a mix …

Although leukemia is the most common childhood cancer diagnosis, the subtype, acute
myeloid leukemia (AML), is less common and fewer etiologic studies exist. This review …

Abstract Purpose of Review At elevated levels, the essential element manganese (Mn) is
neurotoxic and increasing evidence indicates that environmental Mn exposure early in life …

Variation in drug efficacy and toxicity remains an important clinical concern. Presently, single
nucleotide polymorphisms (SNPs) only explain a portion of this problem, even in situations …

Phase I and II drug metabolizing enzymes (DME) and drug transporters are involved in the
absorption, distribution, metabolism as well as elimination of many therapeutic agents …

The input into the QIVIVE and Physiologically-Based kinetic and dynamic models of drug
metabolising enzymes performance and their inter-individual differences significantly …

Glutathione S-transferase Mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1)
enzymes are glutathione-S-transferases with broad significance for susceptibility or …

Azathioprine is a purine antimetabolite drug commonly used to treat inflammatory bowel
disease (IBD). In vivo it is active after reaction with reduced glutathione (GSH) and …

Genetic diversity in drug metabolism and disposition is mainly considered as the outcome of
the inter-individual genetic variation in polymorphism of drug-xenobiotic metabolizing …

Glutathione S-Transferase enzymes (GSTs) constitute the principal Phase II superfamily
which plays a key role in cellular detoxification and in other biological processes. Studies of …