Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

MDA Paskeh, M Entezari, S Mirzaei, A Zabolian… - Journal of hematology & …, 2022 - Springer
Cancer is one of the leading causes of death worldwide, and the factors responsible for its
progression need to be elucidated. Exosomes are structures with an average size of 100 nm …

Hypoxia induced changes of exosome cargo and subsequent biological effects

H Jiang, H Zhao, M Zhang, Y He, X Li, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Exosomes are small extracellular vesicles that are secreted by almost all types of cells and
exist in almost all extracellular spaces. As an important mediator of intercellular …

RETRACTED ARTICLE: The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA

Z Feng, K Li, K Qin, J Liang, M Shi, Y Ma… - Journal of hematology & …, 2022 - Springer
Background Although a substantial increase in the survival of patients with other cancers
has been observed in recent decades, pancreatic ductal adenocarcinoma (PDAC) remains …

Impact of epigenetic reprogramming on antitumor immune responses in glioma

BL McClellan, S Haase, FJ Nunez… - The Journal of …, 2023 - Am Soc Clin Investig
Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a
key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis …

METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt/β-catenin signaling

J Yin, F Ding, Z Cheng, X Ge, Y Li, A Zeng… - Cell death & …, 2023 - nature.com
Long noncoding RNAs (lncRNAs) are involved in glioma initiation and progression. Glioma
stem cells (GSCs) are essential for tumor initiation, maintenance, and therapeutic resistance …

Molecular mechanisms of drug resistance in glioblastoma

MA Dymova, EV Kuligina, VA Richter - International journal of molecular …, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly
resistant to conventional radiation and chemotherapy, and is not amenable to effective …

Biological, diagnostic and therapeutic implications of exosomes in glioma

CL Davidson, R Vengoji, M Jain, SK Batra, N Shonka - Cancer letters, 2024 - Elsevier
Despite therapeutic advances, overall survival in glioblastoma is dismal. To optimize
progress, a more detailed understanding of glioma's molecular, cellular, and intercellular …

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

X Guo, R Sui, H Piao - Journal of Nanobiotechnology, 2022 - Springer
Small extracellular vesicles (SEVs) are extracellular vesicles containing DNA, RNA, and
proteins and are involved in intercellular communication and function, playing an essential …

Exosomal lncRNA HMMR‐AS1 mediates macrophage polarization through miR‐147a/ARID3A axis under hypoxia and affects the progression of hepatocellular …

X Wang, Y Zhou, K Dong, H Zhang… - Environmental …, 2022 - Wiley Online Library
Background At present, the role of lncRNA in different kinds of tumors has been widely
reported, but its role with hypoxic environment and macrophage polarization is still unclear …

Tumor‐associated macrophage‐derived Exosomal LINC01232 induces the immune escape in glioma by decreasing surface MHC‐I expression

J Li, K Wang, C Yang, K Zhu, C Jiang… - Advanced …, 2023 - Wiley Online Library
Tumor‐associated macrophage (TAM) infiltration facilitates glioma malignancy, but the
underlying mechanisms remain unclear. Herein, it is reported that TAMs secrete exosomal …