Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

The complete and faithful duplication of the genome is an essential prerequisite for
proliferating cells to maintain genome integrity. This objective is greatly challenged by DNA …

The post-translational modification of proteins by SUMO is crucial for cellular viability and
mammalian development in part due to the contribution of SUMOylation to genome …

Abstract The Mus81-Mms4 nuclease is activated in G2/M via Mms4 phosphorylation to allow
resolution of persistent recombination structures. However, the fate of the activated …

Complete genome duplication in every cell cycle is fundamental for genome stability and
cell survival. However, chromosome replication is frequently challenged by obstacles that …

Replication of a damaged DNA template can threaten the integrity of the genome, requiring
the use of various mechanisms to tolerate DNA lesions. The Smc5/6 complex, together with …

Structure-specific endonucleases contribute to the maintenance of genome integrity by
cleaving DNA intermediates that need to be resolved for faithful DNA repair, replication, or …

MUS81 is an important structure-specific endonuclease responsible for the processing of
stalled replication forks and recombination intermediates. In human, MUS81 functions by …

The execution of recombinational pathways during the repair of certain DNA lesions or in the
meiotic program is associated to the formation of joint molecules that physically hold …

SUMO modification regulates diverse cellular processes by targeting hundreds of proteins.
However, the limited number of sumoylation enzymes raises the question of how such a …