Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The object of this review is to assemble much of the literature concerning Purkinje cell death
in cerebellar pathology and to relate this to what is now known about the complex …

Elucidation of molecular mechanisms that regulate synapse formation is required for the
understanding of neural wiring, higher brain functions, and mental disorders. Despite the …

Lurcher (Lc) is a spontaneous, semidominant mouse neurological mutation. Heterozygous
Lurcher mice (Lc/+) display ataxia as a result of a selective, cell-autonomous and apoptotic …

Monocarboxylate transporters (MCTs) play an important role in the metabolism of all cells.
They mediate the transport of lactate and pyruvate but also some other substrates such as …

ATP mediates fast excitatory synaptic transmission in some regions of the central nervous
system through activation of P2X receptors. Nonetheless, the functional significance of ATP …

Messenger RNA m6A modification is shown to regulate local translation in axons. However,
how the m6A codes in axonal mRNAs are read and decoded by the m6A reader proteins is …

The glutamate receptor δ2 subunit (GluRδ2) is specifically expressed in cerebellar Purkinje
cells (PCs) from early developmental stages and is selectively localized at dendritic spines …

Cerebral palsy due to perinatal injury to cerebral white matter is usually not caused by
genetic mutations, but by ischemia and/or inflammation. Here, we describe an autosomal …

Purkinje cell (PC) dysfunction or degeneration is the most frequent finding in animal models
with ataxic symptoms. Mutations affecting intrinsic membrane properties can lead to ataxia …