MicroRNAs in kidney injury and disease

N Mahtal, O Lenoir, C Tinel, D Anglicheau… - Nature Reviews …, 2022 - nature.com
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by
degrading or repressing the translation of their target messenger RNAs. As miRNAs are …

Emerging roles of exosomal miRNAs in diabetes mellitus

X He, G Kuang, Y Wu, C Ou - Clinical and translational …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by
almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids …

Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications

YX Xu, SD Pu, X Li, ZW Yu, YT Zhang, XW Tong… - Pharmacological …, 2022 - Elsevier
Exosomes are discoid vesicles with a diameter of 40–160 nm. They are mainly derived from
the multivesicular body formed by the invagination of lysosomal particles in the cell, which …

Three-dimensional hierarchical plasmonic nano-architecture based label-free surface-enhanced Raman spectroscopy detection of urinary exosomal miRNA for …

WH Kim, JU Lee, MJ Jeon, KH Park, SJ Sim - Biosensors and Bioelectronics, 2022 - Elsevier
The urinary exosomal miRNAs are recently emerging prostate cancer (PC)-associated
biomarkers for the early-stage diagnosis and prognosis due to their non-invasiveness …

[HTML][HTML] Stem cell-derived and circulating exosomal microRNAs as new potential tools for diabetic nephropathy management

L Peng, Y Chen, S Shi, H Wen - Stem Cell Research & Therapy, 2022 - Springer
Background Despite major advances in the treatment of diabetic nephropathy (DN) in recent
years, it remains the most common cause of end-stage renal disease. An early diagnosis …

[HTML][HTML] MicroRNAs in chronic kidney disease: four candidates for clinical application

LJF Peters, J Floege, EAL Biessen… - International journal of …, 2020 - mdpi.com
There are still major challenges regarding the early diagnosis and treatment of chronic
kidney disease (CKD), which is in part due to the fact that its pathophysiology is very …

[HTML][HTML] Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications

J Liu, Y Zhang, Y Tian, W Huang, N Tong, X Fu - Theranostics, 2022 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a chronic systemic disease with increasing prevalence globally.
An important aspect of diabetic pathogenesis is cellular crosstalk and information exchange …

[HTML][HTML] MicroRNA-21: A critical pathogenic factor of diabetic nephropathy

S Liu, W Wu, J Liao, F Tang, G Gao, J Peng… - Frontiers in …, 2022 - frontiersin.org
Diabetic nephropathy (DN), one of the most common and intractable microvascular
complications of diabetes, is the main cause of terminal renal disease globally. MicroRNA …

CD31+ Extracellular Vesicles From Patients With Type 2 Diabetes Shuttle a miRNA Signature Associated With Cardiovascular Complications

F Prattichizzo, V De Nigris, J Sabbatinelli, A Giuliani… - Diabetes, 2021 - Am Diabetes Assoc
Innovative biomarkers are needed to improve the management of patients with type 2
diabetes mellitus (T2DM). Blood circulating miRNAs have been proposed as a potential tool …

MicroRNAs and their delivery in diabetic fibrosis

A Wonnacott, L Denby, RJM Coward, DJ Fraser… - Advanced Drug Delivery …, 2022 - Elsevier
The global prevalence of diabetes mellitus was estimated to be 463 million people in 2019
and is predicted to rise to 700 million by 2045. The associated financial and societal costs of …