Streptomyces: The biofactory of secondary metabolites

K Alam, A Mazumder, S Sikdar, YM Zhao… - Frontiers in …, 2022 - frontiersin.org
Natural products derived from microorganisms serve as a vital resource of valuable
pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial …

Recently Discovered Secondary Metabolites from Streptomyces Species

HJ Lacey, PJ Rutledge - Molecules, 2022 - mdpi.com
The Streptomyces genus has been a rich source of bioactive natural products, medicinal
chemicals, and novel drug leads for three-quarters of a century. Yet studies suggest that the …

Artificial intelligence-guided discovery of anticancer lead compounds from plants and associated microorganisms

G Li, P Lin, K Wang, CC Gu, S Kusari - Trends in Cancer, 2022 - cell.com
Plants and associated microorganisms are essential sources of natural products against
human cancer diseases, partly exemplified by plant-derived anticancer drugs such as Taxol …

Streptomyces sp.—A Treasure Trove of Weapons to Combat Methicillin-Resistant Staphylococcus aureus Biofilm Associated with Biomedical Devices

P Pusparajah, V Letchumanan, JWF Law… - International journal of …, 2021 - mdpi.com
Biofilms formed by methicillin-resistant S. aureus (MRSA) are among the most frequent
causes of biomedical device-related infection, which are difficult to treat and are often …

Cytotoxic Peptaibols from Trichoderma strigosum

YS Park, ES Kim, ST Deyrup, JW Lee… - Journal of Natural …, 2024 - ACS Publications
Five new lipopeptaibols (1–5) and eight new 19-residue peptaibols (8–15) along with two
known lipopeptaibols, lipovelutibols C (6) and D (7) were isolated from Trichoderma …

The Chemistry of Angucyclines

D Vysloužilová, O Kováč - ChemPlusChem, 2024 - Wiley Online Library
Angucyclines and angucyclinones represent a class of natural compounds that belong to the
group of aromatic polyketides. They exhibit a wide array of biological properties, such as …

Angucyclinones with IDO and TDO inhibitory activities isolated from the actinomycetes Umezawaea beigongshangensis

PR Cao, X Ren, J Lin, YL Mu, YQ Shan, JT Zhu, RY Xu… - Fitoterapia, 2024 - Elsevier
Four previously undescribed angucyclinones umezawaones AD (1–4) were isolated from
the liquid cultures of Umezawaea beigongshangensis. Their structures were determined by …

[HTML][HTML] Bioactive Angucyclines/Angucyclinones Discovered from 1965 to 2023

HS Liu, HR Chen, SS Huang, ZH Li, CY Wang… - Marine …, 2025 - pmc.ncbi.nlm.nih.gov
Angucyclines/angucyclinones, a class of polyketides with diverse chemical structures,
display various bioactivities including antibacterial or antifungal, anticancer, anti …

Streptomyces griseus KJ623766: A Natural Producer of Two Anthracycline Cytotoxic Metabolites β- and γ-Rhodomycinone

ASA Zaid, AE Aleissawy, IS Yahia, MA Yassien… - Molecules, 2021 - mdpi.com
Background: This study aimed to produce, purify, structurally elucidate, and explore the
biological activities of metabolites produced by Streptomyces (S.) griseus isolate KJ623766 …

[PDF][PDF] Artificial Intelligence-Guided Discovery of Anticancer Compounds from Marine Plants: A Focus on Sargassum SPP

A Mittal - 2024 - researchgate.net
The exploration of marine plants as sources of novel anticancer compounds has gained
significant attention due to their diverse biochemical compositions and unique ecological …