Vesicle exocytosis releases content to mediate many biological events, including synaptic
transmission essential for brain functions. Following exocytosis, endocytosis is initiated to …

Neurons can sustain high rates of synaptic transmission without exhausting their supply of
synaptic vesicles. This property relies on a highly efficient local endocytic recycling of …

Mice carrying a mutation in the synaptotagmin I gene were generated by homologous
recombination. Mutant mice are phenotypically normal as heterozygotes, but die within 48 …

Ultrafast endocytosis can retrieve a single, large endocytic vesicle as fast as 50–100 ms
after synaptic vesicle fusion. However, the fate of the large endocytic vesicles is not known …

▪ Abstract Endocytosis in eukaryotic cells is characterized by the continuous and regulated
formation of prolific numbers of membrane vesicles at the plasma membrane. These …

Communication between cells reaches its highest degree of specialization at chemical
synapses. Some synapses talk in a'whisper'; others' shout'. The'louder'the synapse, the more …

The synaptic vesicle cycle at the nerve terminal consists of vesicle exocytosis with neuro-
transmitter release, endocytosis of empty vesicles, and regeneration of fresh vesicles. Of all …

EXCITATORY amino-acid transporters (EAATs) in the central nervous system maintain
extracellular glutamate concentrations below excitotoxic levels and may limit the activation …

Growing evidence suggests that phosphoinositides play an important role in membrane
traffic. A polyphosphoinositide phosphatase, synaptojanin 1, was identified as a major …

The C2 domain is a Ca2+‐binding motif of approximately 130 residues in length originally
identified in the Ca2+‐dependent isoforms of protein kinase C. Single and multiple copies of …