The continuum of aging and age-related diseases: common mechanisms but different rates
Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
Inflammaging and anti-inflammaging: the role of cytokines in extreme longevity
PL Minciullo, A Catalano, G Mandraffino… - Archivum immunologiae …, 2016 - Springer
Longevity and aging are two sides of the same coin, as they both derive from the interaction
between genetic and environmental factors. Aging is a complex, dynamic biological process …
between genetic and environmental factors. Aging is a complex, dynamic biological process …
Gut microbiota and extreme longevity
The study of the extreme limits of human lifespan may allow a better understanding of how
human beings can escape, delay, or survive the most frequent age-related causes of …
human beings can escape, delay, or survive the most frequent age-related causes of …
Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians
Background Age-related physiological changes in the gastrointestinal tract, as well as
modifications in lifestyle, nutritional behaviour, and functionality of the host immune system …
modifications in lifestyle, nutritional behaviour, and functionality of the host immune system …
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low …
imbalance between inflammatory and anti-inflammatory networks, which results in the low …
Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine
R Ostan, D Monti, P Gueresi, M Bussolotto… - Clinical …, 2016 - portlandpress.com
Data showing a remarkable gender difference in life expectancy and mortality, including
survival to extreme age, are reviewed starting from clinical and demographic data and …
survival to extreme age, are reviewed starting from clinical and demographic data and …
[HTML][HTML] Functional metagenomic profiling of intestinal microbiome in extreme ageing
Age-related alterations in human gut microbiota composition have been thoroughly
described, but a detailed functional description of the intestinal bacterial coding capacity is …
described, but a detailed functional description of the intestinal bacterial coding capacity is …
Effects of natural aging and gender on pro-inflammatory markers
JC Milan-Mattos, FF Anibal, NM Perseguini… - Brazilian Journal of …, 2019 - SciELO Brasil
The term inflammaging is now widely used to designate the inflammatory process of natural
aging. During this process, cytokine balance is altered, presumably due to the loss of …
aging. During this process, cytokine balance is altered, presumably due to the loss of …
Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span
SL Andersen, P Sebastiani, DA Dworkis… - … Series A: Biomedical …, 2012 - academic.oup.com
We analyze the relationship between age of survival, morbidity, and disability among
centenarians (age 100–104 years), semisupercentenarians (age 105–109 years), and …
centenarians (age 100–104 years), semisupercentenarians (age 105–109 years), and …
Association of FOXO3A variation with human longevity confirmed in German centenarians
F Flachsbart, A Caliebe, R Kleindorp… - Proceedings of the …, 2009 - National Acad Sciences
The human forkhead box O3A gene (FOXO3A) encodes an evolutionarily conserved key
regulator of the insulin–IGF1 signaling pathway that is known to influence metabolism and …
regulator of the insulin–IGF1 signaling pathway that is known to influence metabolism and …