Additive manufacturing pertaining to bone: Hopes, reality and future challenges for clinical applications

B Charbonnier, M Hadida, D Marchat - Acta Biomaterialia, 2021 - Elsevier
For the past 20 years, the democratization of additive manufacturing (AM) technologies has
made many of us dream of: low cost, waste-free, and on-demand production of functional …

Process analytical technologies in cell therapy manufacturing: State‐of‐the‐art and future directions

B Wang, AC Bowles‐Welch, C Yeago… - Journal of Advanced …, 2022 - Wiley Online Library
Cell therapies have the potential to effectively treat and even cure complex, currently
untreatable diseases with unprecedented success. The cell therapy industry has been …

Vertebrate cell culture as an experimental approach–limitations and solutions

M Abbas, F Moradi, W Hu, KL Regudo… - … and Physiology Part B …, 2021 - Elsevier
Mammalian cell culture has provided the foundation for the incredible expansion of cell
biology to uncover the 'inner life of the cell'. The protocols for propagating cells in the …

Advances in manufacturing cardiomyocytes from human pluripotent stem cells

ME Floy, F Shabnam, AD Simmons… - Annual review of …, 2022 - annualreviews.org
The emergence of human pluripotent stem cell (hPSC) technology over the past two
decades has provided a source of normal and diseased human cells for a wide variety of in …

Decision support tools for next-generation vaccines and advanced therapy medicinal products: present and future

M Sarkis, A Bernardi, N Shah… - Current Opinion in …, 2021 - Elsevier
Advanced Therapy Medicinal Products (ATMPs) are a novel class of biological therapeutics
that utilise ground-breaking clinical interventions to prevent and treat life-threatening …

Thymidylate synthase disruption to limit cell proliferation in cell therapies

R Sartori-Maldonado, H Montaser, I Soppa, S Eurola… - Molecular Therapy, 2024 - cell.com
Stem and progenitor cells hold great promise for regenerative medicine and gene therapy
approaches. However, transplantations of living cells entail a fundamental risk of unwanted …

Exploring User Interactions in AR/VR Interfaces: A Simulation-Based Study

S Zandi, GA Luhan - 2023 International Conference on …, 2023 - ieeexplore.ieee.org
Virtual Reality (VR) and Augmented Reality (AR) technologies have gained significant
attention in various domains. User interactions and error rates in VR/AR environments are …

Reinforcement learning‐guided control strategies for CAR T‐cell activation and expansion

S Ferdous, IF Shihab, R Chowdhury… - Biotechnology and …, 2024 - Wiley Online Library
Reinforcement learning (RL), a subset of machine learning (ML), could optimize and control
biomanufacturing processes, such as improved production of therapeutic cells. Here, the …

Current status and opportunities in adaptive data analysis for therapeutic cell manufacturing

Z Liu, J Chen, K Wang, B Wang, C Zhang - Current Opinion in Biomedical …, 2021 - Elsevier
As an emerging technology, therapeutic cell manufacturing faces major challenges in three
aspects, knowledge gap, regulations, and case-to-case variability. Among all variability …

Mesenchymal stem cell-based heart cell therapy: the effect of route of cell delivery in the clinical perspective

YMN Kalou, ASA Hashemi, RM Joudeh… - Stem cells: from …, 2021 - Springer
Bone marrow-derived mesenchymal stem cells are one of the most extensively
characterized cell types in vitro as well in the experimental animal models. During the last …