Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

H Lu, Q Zhou, J He, Z Jiang, C Peng, R Tong… - Signal transduction and …, 2020 - nature.com
Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences

C Manzoni, DA Kia, J Vandrovcova… - Briefings in …, 2018 - academic.oup.com
Advances in the technologies and informatics used to generate and process large biological
data sets (omics data) are promoting a critical shift in the study of biomedical sciences. While …

Rational design of peptide-based inhibitors disrupting protein-protein interactions

X Wang, D Ni, Y Liu, S Lu - Frontiers in chemistry, 2021 - frontiersin.org
Protein-protein interactions (PPIs) are well-established as a class of promising drug targets
for their implications in a wide range of biological processes. However, drug development …

Computational approaches for the design of modulators targeting protein-protein interactions

AU Rehman, B Khurshid, Y Ali, S Rasheed… - Expert opinion on …, 2023 - Taylor & Francis
ABSTRACT Background Protein-protein interactions (PPIs) are intriguing targets for
designing novel small-molecule inhibitors. The role of PPIs in various infectious and …

Knowledge graphs: A practical review of the research landscape

M Kejriwal - Information, 2022 - mdpi.com
Knowledge graphs (KGs) have rapidly emerged as an important area in AI over the last ten
years. Building on a storied tradition of graphs in the AI community, a KG may be simply …

Reconstruction methods for networks: The case of economic and financial systems

T Squartini, G Caldarelli, G Cimini, A Gabrielli… - Physics reports, 2018 - Elsevier
The study of social, economic and biological systems is often (when not always) limited by
the partial information about the structure of the underlying networks. An example of …

Emerging roles of allosteric modulators in the regulation of protein‐protein interactions (PPIs): A new paradigm for PPI drug discovery

D Ni, S Lu, J Zhang - Medicinal research reviews, 2019 - Wiley Online Library
Protein‐protein interactions (PPIs) are closely implicated in various types of cellular activities
and are thus pivotal to health and disease states. Given their fundamental roles in a wide …

[HTML][HTML] Targeting protein–protein interactions, a wide open field for drug design

M Bakail, F Ochsenbein - Comptes …, 2016 - comptes-rendus.academie-sciences …
Targeting protein–protein interactions has long been considered as a very difficult if
impossible task, but over the past decade, front lines have moved. The number of successful …

ComPPI: a cellular compartment-specific database for protein–protein interaction network analysis

DV Veres, DM Gyurkó, B Thaler, KZ Szalay… - Nucleic acids …, 2015 - academic.oup.com
Here we present ComPPI, a cellular compartment-specific database of proteins and their
interactions enabling an extensive, compartmentalized protein–protein interaction network …

What can proteomics tell us about platelets?

JM Burkhart, S Gambaryan, SP Watson, K Jurk… - Circulation …, 2014 - Am Heart Assoc
More than 130 years ago, it was recognized that platelets are key mediators of hemostasis.
Nowadays, it is established that platelets participate in additional physiological processes …