Pin1 is a highly conserved enzyme that only isomerizes specific phosphorylated Ser/Thr-Pro
bonds in certain proteins, thereby inducing conformational changes. Such conformational …

In the recent years, knowledge about cancer biomarkers has increased tremendously
providing great opportunities for improving the management of cancer patients by …

Phosphorylation of proteins on serine or threonine residues preceding proline (pSer/Thr-
Pro) is a major regulatory mechanism in cell proliferation and transformation. Interestingly …

Proline-directed phosphorylation is a posttranslational modification that is instrumental in
regulating signaling from the plasma membrane to the nucleus, and its dysregulation …

PIN1 is a peptidyl-prolyl isomerase that can alter the conformation of phosphoproteins and
so affect protein function and/or stability. PIN1 regulates a number of proteins important for …

Protein phosphorylation on certain serine or threonine residues preceding proline (Ser/Thr-
Pro) is a pivitol signaling mechanism in diverse cellular processes and its deregulation can …

Phosphorylation of proteins on serine or threonine residues preceding proline is a key
signalling mechanism in diverse physiological and pathological processes. Pin1 (peptidyl …

Background and Aims Intrahepatic cholangiocarcinoma (iCCA) and hepatocellular
carcinoma (HCC) are the most common primary liver cancers (PLCs). Differences in their …

Polyphenols such as epigallocatechin-3-gallate (EGCG) from green tea extract can exert a
growth-suppressive effect on human pancreatic cancer cells in vitro. In pursuit of our …

Phosphorylation of proteins on serine or threonine residues preceding proline (Ser/Thr-Pro)
is a major intracellular signaling mechanism. The phosphorylated Ser/Thr-Pro motifs in a …