Nanotherapeutic intervention in photodynamic therapy for cancer

AM Itoo, M Paul, SG Padaga, B Ghosh, S Biswas - ACS omega, 2022 - ACS Publications
The clinical need for photodynamic therapy (PDT) has been growing for several decades.
Notably, PDT is often used in oncology to treat a variety of tumors since it is a low-risk …

Cancer metabolism: the role of ROS in DNA damage and induction of apoptosis in cancer cells

Y Zhao, X Ye, Z Xiong, A Ihsan, I Ares, M Martínez… - Metabolites, 2023 - mdpi.com
Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS)
levels are a recognized hallmark of cancer and an important aspect of cancer treatment …

Redox interactions of vitamin C and iron: Inhibition of the pro-oxidant activity by deferiprone

VA Timoshnikov, TV Kobzeva, NE Polyakov… - International journal of …, 2020 - mdpi.com
Ascorbic acid (AscH2) is one of the most important vitamins found in the human diet, with
many biological functions including antioxidant, chelating, and coenzyme activities. Ascorbic …

Trying to solve the puzzle of the interaction of ascorbic acid and iron: Redox, chelation and therapeutic implications

GJ Kontoghiorghes, A Kolnagou, CN Kontoghiorghe… - Medicines, 2020 - mdpi.com
Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth and
development of humans, and their deficiency can result in serious diseases. Their …

Mechanistic insights of chelator complexes with essential transition metals: antioxidant/pro-oxidant activity and applications in medicine

VA Timoshnikov, OY Selyutina, NE Polyakov… - International Journal of …, 2022 - mdpi.com
The antioxidant/pro-oxidant activity of drugs and dietary molecules and their role in the
maintenance of redox homeostasis, as well as the implications in health and different …

New iron metabolic pathways and chelation targeting strategies affecting the treatment of all types and stages of cancer

GJ Kontoghiorghes - International Journal of Molecular Sciences, 2022 - mdpi.com
There is new and increasing evidence from in vitro, in vivo and clinical studies implicating
the pivotal role of iron and associated metabolic pathways in the initiation, progression and …

A Carbon‐Carbon Bond Cleavage‐Based Prodrug Activation Strategy Applied to β‐Lapachone for Cancer‐Specific Targeting

Q Gong, X Li, T Li, X Wu, J Hu, F Yang… - Angewandte …, 2022 - Wiley Online Library
Prodrugs are one of the most common strategies for the design of targeted anticancer
agents. However, their application is often hampered by the modifiable groups available on …

Aqueous Redox Flow Batteries: Small Organic Molecules for the Positive Electrolyte Species

CG Cannon, PAA Klusener, NP Brandon… - …, 2023 - Wiley Online Library
There are a number of critical requirements for electrolytes in aqueous redox flow batteries.
This paper reviews organic molecules that have been used as the redox‐active electrolyte …

Triptolide induces glioma cell autophagy and apoptosis via upregulating the ROS/JNK and downregulating the Akt/mTOR signaling pathways

X Liu, P Zhao, X Wang, L Wang, Y Zhu, W Gao - Frontiers in oncology, 2019 - frontiersin.org
Apoptosis and autophagy are the two prominent forms of developmental cell death, and
researches have shown that crosstalk exists between these two processes. A prior study …

The Interaction of Anthracycline Based Quinone-Chelators with Model Lipid Membranes: 1H NMR and MD Study

OY Selyutina, AV Mastova, NE Polyakov - Membranes, 2023 - mdpi.com
Anthracycline antibiotics, eg, doxorubicin, daunomycin, and other anthraquinones, are an
important family of antitumor agents widely used in chemotherapy, which is currently the …