Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

Adiponectin is the richest adipokine in human plasma, and it is mainly secreted from white
adipose tissue. Adiponectin circulates in blood as high-molecular, middle-molecular, and …

Chronic, excessive neuroinflammation is a key feature of neurodegenerative diseases such
as Alzheimer's disease (AD) and Parkinson's disease (PD). However, neuroinflammatory …

Adiponectin is an adipocyte-specific factor, first described in 1995. Over the past two
decades, numerous studies have elucidated the physiological functions of adiponectin in …

Background The most common type of monogenic diabetes is maturity-onset diabetes of the
young (MODY), a clinically and genetically heterogeneous group of endocrine disorders that …

The growing prevalence of metabolic syndrome (MetS) in the US and even worldwide is
becoming a serious health problem and economic burden. MetS has become a crucial risk …

Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …

Obesity-linked type 2 diabetes is one of the paramount causes of morbidity and mortality
worldwide, posing a major threat on human health, productivity, and quality of life. Despite …

Insulin resistance is a systemic disorder that affects many organs and insulin-regulated
pathways. The disorder is characterized by a reduced action of insulin despite increased …

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
worldwide, as it affects up to 30% of adults in Western countries. Moreover, NAFLD is also …