[HTML][HTML] Olea europaea L-derived secoiridoids: Beneficial health effects and potential therapeutic approaches

S Filardo, M Roberto, D Di Risola, L Mosca… - Pharmacology & …, 2024 - Elsevier
Over the years, health challenges have become increasingly complex and global and, at the
beginning of the 21st century, chronic diseases, including cardiovascular, neurological, and …

Oleocanthal–Characterization, production, safety, functionality and in vivo evidences

F Rivero-Pino - Food Chemistry, 2023 - Elsevier
Abstract Oleocanthal, OC, 2‐(4‐Hydroxyphenyl) ethyl (3S, 4E)‐4‐formyl‐3‐(2‐oxoethyl) hex‐
4‐enoate, is a natural organic compound exclusively found in Olea europaea …

The effect of dietary intervention with high-oleocanthal and oleacein olive oil in patients with early-stage chronic lymphocytic leukemia: A pilot randomized trial

AP Rojas Gil, I Kodonis, A Ioannidis, T Nomikos… - Frontiers in …, 2022 - frontiersin.org
Aim Oleocanthal and oleacein (OC/OL) have important in vitro and in vivo antitumor
properties; however, there is no data about their anticancer activity in humans. The aim of …

New affordable methods for large-scale isolation of major olive secoiridoids and systematic comparative study of their antiproliferative/cytotoxic effect on multiple …

A Papakonstantinou, P Koumarianou… - International Journal of …, 2022 - mdpi.com
Olive oil phenols (OOPs) are associated with the prevention of many human cancers. Some
of these have been shown to inhibit cell proliferation and induce apoptosis. However, no …

Tissue distribution of oleocanthal and its metabolites after oral ingestion in rats

A López-Yerena, A Vallverdú-Queralt, O Jáuregui… - Antioxidants, 2021 - mdpi.com
Claims for the potential health benefits of oleocanthal (OLC), a dietary phenolic compound
found in olive oil, are based mainly on in vitro studies. Little is known about the tissue …

S-(−)-Oleocanthal Ex Vivo Modulatory Effects on Gut Microbiota

MH Qusa, KS Abdelwahed, RA Hill, KA El Sayed - Nutrients, 2023 - mdpi.com
Compelling evidence points to the critical role of bioactive extra-virgin olive oil (EVOO)
phenolics and gut microbiota (GM) interplay, but reliable models for studying the …

Pharmacokinetics and Metabolism Investigation of Oleocanthal

T Nikou, KV Karampetsou, OS Koutsoni… - Journal of Natural …, 2023 - ACS Publications
Oleocanthal is a secoiridoid found in olive oil, which lately gained great scientific interest
due to its important pharmacological spectrum and biological properties. However, limited …

Oleocanthal Ameliorates Metabolic and Behavioral Phenotypes in a Mouse Model of Alzheimer's Disease

E Yang, J Wang, LN Woodie, MW Greene, A Kaddoumi - Molecules, 2023 - mdpi.com
Aging is a major risk factor for Alzheimer's disease (AD). AD mouse models are frequently
used to assess pathology, behavior, and memory in AD research. While the pathological …

Oleocanthal Ameliorates Metabolic and Behavior Phenotypes in a Mouse Model of Alzheimer's Disease

E Yang, J Wang, LN Woodie, MW Greene, A Kaddoumi - 2023 - preprints.org
Aging is a major risk factor for Alzheimer's disease (AD). AD mouse models are frequently
used to assess pathology, behavior, and memory in AD research. While the pathological …

[PDF][PDF] S-(−)-Oleocanthal Ex Vivo Modulatory Effects on Gut Microbiota. Nutrients 2023, 15, 618

MH Qusa, KS Abdelwahed, RA Hill, KA El Sayed - 2023 - researchgate.net
Compelling evidence points to the critical role of bioactive extra-virgin olive oil (EVOO)
phenolics and gut microbiota (GM) interplay, but reliable models for studying the …