Chimeric antigen receptor (CAR) T-cell therapy has yielded impressive outcomes and
transformed treatment algorithms for hematological malignancies. To date, five CAR T-cell …

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Physical trauma can affect any individual and is globally accountable for more than one in
every ten deaths. Although direct severe kidney trauma is relatively infrequent, extrarenal …

Discovered almost 40 years ago, the potent vasoconstrictor peptide endothelin-1 (ET-1) has
a wide range of roles both physiologically and pathologically. In recent years, there has …

Unrestrained activation of the complement system till the terminal products, C5a and C5b-9,
plays a pathogenetic role in acute and chronic inflammatory diseases. In endothelial cells …

Rationale: PAD4 (peptidylarginine deiminase type IV), an enzyme essential for neutrophil
extracellular trap formation (NETosis), is released together with neutrophil extracellular traps …

The accumulation of low-density lipoproteins (LDL) in the arterial wall plays a pivotal role in
the initiation and pathogenesis of atherosclerosis. Conversely, the removal of cholesterol …

Vascular endothelial cells produce and release compounds regulating vascular tone, blood
vessel growth and differentiation, plasma composition, coagulation and fibrinolysis, and also …