Gout is well known as an inflammatory rheumatic disease presenting with arthritis and
abnormal metabolism of uric acid. The recognition of diet-induced systemic metabolic …

Cardiovascular diseases (CVDs) rank the leading cause of morbidity and mortality globally.
Obesity and its related metabolic syndrome are well-established risk factors for CVDs …

Brain metabolism perturbation can contribute to traits and diseases. We conducted a
genome-wide association study for cerebrospinal fluid (CSF) and brain metabolite levels …

Obesity is a growing health concern in today's society. Current estimates indicate that
obesity occurs in both adults and young people. Recent research also found that the …

Oxidative stress is assumed to be the underlying feature of non-alcoholic fatty liver disease
(NAFLD). To our knowledge, the mutual involvement of redox status homeostasis …

In the present study, we investigated the effects of xanthine oxidase (XO) inhibition on
cholesterol-induced renal dysfunction in chronic kidney disease (CKD) mice, and in low …

Resistance to high-fat diet-induced obesity (DIR) has been observed in mice fed a high-fat
diet and may provide a potential approach for anti-obesity drug discovery. However, the …

Objective. Coronary artery bypass grafting (CABG) represents the significant source of
increased oxidative stress (OS). We aimed to follow the OS status parameters (ie, ischemia …

Different byproducts of oxidative stress do not always lead to the same conclusion regarding
its relationship with cardiometabolic risk, since controversial results are reported so far. The …

The prevalence of insulin resistance and diabetes mellitus is rising globally in epidemic
proportions. Diabetes and its complications contribute to significant morbidity and mortality …