Innate immunological pathways in COVID-19 pathogenesis

SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …

Innate immunity in protection and pathogenesis during coronavirus infections and COVID-19

RKS Malireddi, BR Sharma… - Annual Review of …, 2024 - annualreviews.org
The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …

COVID-19 disease and immune dysregulation

E Davitt, C Davitt, MB Mazer, SS Areti… - Best Practice & …, 2022 - Elsevier
The SARS-CoV-2 virus has complex and divergent immune alterations in differing hosts and
over disease evolution. Much of the nuanced COVID-19 disease immune dysregulation was …

[HTML][HTML] Complement activation in COVID-19 and targeted therapeutic options: a scoping review

EHT Lim, RBE van Amstel, VV de Boer, LA van Vught… - Blood Reviews, 2023 - Elsevier
Increasing evidence suggests that activation of the complement system plays a key role in
the pathogenesis and disease severity of Coronavirus disease 2019 (COVID-19). We used a …

The deciphering of the immune cells and marker signature in COVID‐19 pathogenesis: An update

SA Jasim, RS Mahdi, DO Bokov… - Journal of Medical …, 2022 - Wiley Online Library
The precise interaction between the immune system and severe acute respiratory syndrome
coronavirus 2 (SARS‑CoV‑2) is critical in deciphering the pathogenesis of coronavirus …

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID‐19

MK Siggins, K Davies, R Fellows, RS Thwaites… - …, 2023 - Wiley Online Library
Complement, a critical defence against pathogens, has been implicated as a driver of
pathology in COVID‐19. Complement activation products are detected in plasma and …

[HTML][HTML] Complement and COVID-19: Three years on, what we know, what we don't know, and what we ought to know

WM Zelek, RA Harrison - Immunobiology, 2023 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was identified in
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …

[HTML][HTML] Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches

R Ashmawy, EA Hammouda, YA El-Maradny… - Biomolecules, 2024 - mdpi.com
Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2
infection, poses a multifaceted challenge for health. This review explores the intrinsic …

[HTML][HTML] Complement-mediated microvascular injury and thrombosis in the pathogenesis of severe COVID-19: A review

P Gianni, M Goldin, S Ngu, S Zafeiropoulos… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) causes acute microvascular thrombosis in
both venous and arterial structures which is highly associated with increased mortality. The …

Pseudo-targeted metabolomics analysis of the therapeutic effect of phenolics-rich extract from Se-enriched green tea (Camellia sinensis) on LPS-stimulated murine …

Z Fan, W Jia, A Du, L Shi - Food Research International, 2022 - Elsevier
Selenium (Se)-enriched green tea (Se-Te) has been recognized as a possible source of Se
supplements, while the effect of Se enrichment on function of polyphenols in green tea is still …