Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal,
clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in …

Prostate cancer is the second most common malignancy in men worldwide and consists of a
mixture of tumor and non-tumor cell types. To characterize the prostate cancer tumor …

TROP-2 is a glycoprotein first described as a surface marker of trophoblast cells, but
subsequently shown to be increased in many solid cancers, with lower expression in certain …

MYCN amplification and overexpression are common in neuroendocrine prostate cancer
(NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and …

Cellular plasticity contributes to the regenerative capacity of plants, invertebrates, teleost
fishes and amphibians. In vertebrates, differentiated cells are known to revert into replicating …

Tumors are largely classified by histologic appearance, yet morphologic features do not
necessarily predict cellular origin. To determine the origin of pancreatic ductal …

Both solid tumours and leukaemias show considerable histological and functional
heterogeneity. It is widely accepted that genetic lesions have a major role in determining …

Prostate cancer (PCa) is a leading cause of cancer death for males in western countries.
The current gold standard for PCa diagnosis-template needle biopsies-often does not …

Lung squamous cell carcinoma (LSCC) pathogenesis remains incompletely understood,
and biomarkers predicting treatment response remain lacking. Here, we describe novel …