Many lead compounds fail to reach clinical trials despite being potent because of low
bioavailability attributed to their insufficient solubility making solubility a primary and crucial …

In today's pharmaceutical arena, it is estimated that more than 40% of new chemical entities
produced during drug discovery efforts exhibit poor solubility characteristics. However, over …

The objective of this study was to investigate whether the miscibility of a drug and coformer,
as predicted by Hansen solubility parameters (HSPs), can indicate cocrystal formation and …

Purpose Crystallization of drugs formulated in the amorphous form may lead to reduced
apparent solubility, decreased rate of dissolution and bioavailability and compromise the …

The processing parameters for HME have been evaluated and the impact of solid state
intermolecular drug–polymer interactions on supersaturation has been investigated. Poorly …

The aim of this study was to determine the miscibility of drug and excipient to predict if glass
solutions are likely to form when drug and excipient are melt extruded. Two poorly water …

Rapid solvent selection is of great significance in chemistry. However, solubility prediction
remains a crucial challenge. This study aimed to develop machine learning models that can …

The objectives of this study were (i) to develop a computational model based on molecular
dynamics technique to predict the miscibility of indomethacin in carriers (polyethylene oxide …

To establish a method for predicting polymer–drug compatibility as a means to guide
formulation development, we carried out physicochemical analyses of polymer–drug pairs …

Hot-melt extrusion (HME) is a dust-and solvent-free continuous process enabling the
preparation of a variety of solid dosage forms containing solid dispersions of poorly soluble …