Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …

SOX10 belongs to a family of 20 SRY (sex-determining region Y)-related high mobility group
box-containing (SOX) proteins, most of which contribute to cell type specification and …

Premature termination codon (PTC)-bearing transcripts are often degraded by nonsense-
mediated decay (NMD) resulting in loss-of-function (LoF) alleles. However, not all PTCs …

Eukaryotic cells utilize various RNA quality control mechanisms to ensure high fidelity of
gene expression, thus protecting against the accumulation of nonfunctional RNA and the …

Nonsense-mediated decay (NMD) is a pathway that degrades mRNAs containing premature
termination codons. Here we describe a genome-wide screen for NMD factors that uncovers …

Understanding the mechanisms that coordinate stem cell behavior within the host is a high
priority for developmental biology, regenerative medicine and oncology. Endogenous ion …

The general view of development consists of the acquisition of committed/differentiated
phenotypes following a period of self‐renewal and progenitor expansion. Lineage …

Multipass membrane proteins have a myriad of functions, including transduction of cell-cell
signals, ion transport, and photoreception. Insertion of these proteins into the membrane …

Congenital scoliosis (CS) is a birth defect with variable clinical and anatomical
manifestations due to spinal malformation. The genetic etiology underlying about 10% of CS …

Nonstop or stop-loss mutations convert a stop into a sense codon, resulting in translation
into the 3′ untranslated region as a nonstop extension mutation to the next in-frame stop …