The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …

Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …

Yes-associated protein (YAP) is a key mechanotransduction protein in diverse physiological
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …

Aberrations in nuclear size and shape are commonly used to identify cancerous tissue.
However, it remains unclear whether the disturbed nuclear structure directly contributes to …

The cell nucleus is constantly subjected to externally applied forces. During metazoan
evolution, the nucleus has been optimized to allow physical deformability while protecting …

The nucleus in many cell types is a stiff organelle, but fat-filled lipid droplets (FDs) in
cytoplasm are seen to indent and displace the nucleus. FDs are phase-separated liquids …

Cancer cells' ability to migrate through constricting pores in the tissue matrix is limited by
nuclear stiffness. MT1-MMP contributes to metastasis by widening matrix pores, facilitating …

The nuclear envelope safeguards the genetic material inside the nucleus by separating it
from the cytoplasm. Until recently, it was assumed that nuclear envelope (NE) breakdown …

Nuclear morphological features are potent determining factors for clinical diagnostic
approaches adopted by pathologists to analyze the malignant potential of cancer cells …

Increasing evidence demonstrates that mechanical forces, in addition to soluble molecules,
impact cell and tissue functions in physiology and diseases. How living cells integrate …