An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar

ND Grubaugh, K Gangavarapu, J Quick, NL Matteson… - Genome biology, 2019 - Springer
How viruses evolve within hosts can dictate infection outcomes; however, reconstructing this
process is challenging. We evaluate our multiplexed amplicon approach, PrimalSeq, to …

Animal models of Zika virus infection during pregnancy

EA Caine, BW Jagger, MS Diamond - Viruses, 2018 - mdpi.com
Zika virus (ZIKV) emerged suddenly in the Americas in 2015 and was associated with a
widespread outbreak of microcephaly and other severe congenital abnormalities in infants …

Zika virus and the nonmicrocephalic fetus: why we should still worry

CL Walker, MTE Little, JA Roby, B Armistead… - American journal of …, 2019 - Elsevier
Zika virus is a mosquito-transmitted flavivirus and was first linked to congenital microcephaly
caused by a large outbreak in northeastern Brazil. Although the Zika virus epidemic is now …

[HTML][HTML] HSV-1 and Zika virus but not SARS-CoV-2 replicate in the human cornea and are restricted by corneal type III interferon

JJ Miner, DJ Platt, CM Ghaznavi, P Chandra… - Cell Reports, 2020 - cell.com
Here, we report our studies of immune-mediated regulation of Zika virus (ZIKV), herpes
simplex virus 1 (HSV-1), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Exacerbated Zika virus–induced neuropathology and microcephaly in fetuses of dengue-immune nonhuman primates

WAA Saron, K Shanmugam, CC Tung… - Science Translational …, 2023 - science.org
Zika virus (ZIKV) is a mosquito-borne flavivirus that can vertically transmit from mother to
fetus, potentially causing congenital defects, including microcephaly. It is not fully …

A combination of two human monoclonal antibodies prevents Zika virus escape mutations in non-human primates

JR Keeffe, KKA Van Rompay, PC Olsen, Q Wang… - Cell reports, 2018 - cell.com
Zika virus (ZIKV) causes severe neurologic complications and fetal aberrations. Vaccine
development is hindered by potential safety concerns due to antibody cross-reactivity with …

Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques

ME Breitbach, CM Newman, DM Dudley… - PLoS …, 2019 - journals.plos.org
Zika virus (ZIKV) and dengue virus (DENV) are genetically and antigenically related
flaviviruses that now co-circulate in much of the tropical and subtropical world. The rapid …

Animal models of congenital zika syndrome provide mechanistic insight into viral pathogenesis during pregnancy

H Narasimhan, A Chudnovets, I Burd… - PLoS neglected …, 2020 - journals.plos.org
In utero Zika virus (ZIKV; family Flaviviridae) infection causes a distinct pattern of birth
defects and disabilities in the developing fetus and neonate that has been termed congenital …

Nonhuman primate models of Zika virus infection and disease during pregnancy

NN Haese, VHJ Roberts, A Chen, DN Streblow… - Viruses, 2021 - mdpi.com
Since the explosive outbreak of Zika virus in Brazil and South/Central America in 2015–
2016, the frequency of infections has subsided, but Zika virus remains present in this region …

Zika virus infection at mid-gestation results in fetal cerebral cortical injury and fetal death in the olive baboon

S Gurung, N Reuter, A Preno, J Dubaut… - PLoS …, 2019 - journals.plos.org
Zika virus (ZIKV) infection during pregnancy in humans is associated with an increased
incidence of congenital anomalies including microcephaly as well as fetal death and …