Current treatments for Alzheimer's disease (AD) attenuate the progression of symptoms and
aim to improve the patient's quality of life. Licensed medicines are mostly for oral …

Cellular quality control systems have gained much attention in recent decades. Among
these, autophagy is a natural self-preservation mechanism that continuously eliminates toxic …

Ferroptosis and iron-related redox imbalance aggravate traumatic brain injury (TBI)
outcomes. NRF2 is the predominant transcription factor regulating oxidative stress and …

TBI has been one of the top causes of death and morbidity worldwide, yet despite enormous
efforts to discover neuroprotective therapeutics for this serious disease, no beneficial …

Significance: Autophagy and apoptosis are two important cellular mechanisms behind brain
injuries, which are severe clinical situations with increasing incidences worldwide. To …

Stress, which refers to a combination of physiological, neuroendocrine, behavioral, and
emotional responses to novel or threatening stimuli, is essentially a defensive adaptation …

Traumatic brain injury (TBI), a kind of external trauma‐induced brain function alteration, has
posed a financial burden on the public health system. TBI pathogenesis involves a …

Background Traumatic brain injury (TBI) is a major cause of death and disability worldwide.
Oxidative stress, inflammation, and apoptosis are vital pathophysiological features post-TBI …

Excessive iron released by hemoglobin and necrotic tissues is the predominant factor that
aggravates the outcome of traumatic brain injury (TBI). Regulating the levels of iron and its …

Background: Traumatic brain injury (TBI) is a serious hazard to human health and is
characterized by high rates of disability and mortality. It is necessary to explore new effective …