Neurotrophic keratopathy

HS Dua, DG Said, EM Messmer, M Rolando… - Progress in retinal and …, 2018 - Elsevier
Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to
frank epithelial defect with or without stromal ulceration (melting) is associated with reduced …

In vivo confocal microscopy of the cornea: new developments in image acquisition, reconstruction, and analysis using the HRT-Rostock corneal module

WM Petroll, DM Robertson - The ocular surface, 2015 - Elsevier
The optical sectioning ability of confocal microscopy allows high magnification images to be
obtained from different depths within a thick tissue specimen and is thus ideally suited to the …

Corneal confocal microscopy as a quantitative imaging biomarker of diabetic peripheral neuropathy: a review

E Cosmo, G Midena, L Frizziero, M Bruno… - Journal of Clinical …, 2022 - mdpi.com
Distal symmetric polyneuropathy (DPN), particularly chronic sensorimotor DPN, represents
one of the most frequent complications of diabetes, affecting 50% of diabetic patients and …

Potential role of in vivo confocal microscopy for imaging corneal nerves in transthyretin familial amyloid polyneuropathy

A Rousseau, C Cauquil, B Dupas, A Labbé… - JAMA …, 2016 - jamanetwork.com
Importance Small fiber neuropathy (SFN) is an important feature of transthyretin familial
amyloid polyneuropathy (TTR-FAP). A practical and objective method for the clinical …

Pseudomonas aeruginosainduced nociceptor activation increases susceptibility to infection

T Lin, D Quellier, J Lamb, T Voisin, P Baral… - PLoS …, 2021 - journals.plos.org
We report a rapid reduction in blink reflexes during in vivo ocular Pseudomonas aeruginosa
infection, which is commonly attributed and indicative of functional neuronal damage …

Nerve regeneration by human corneal stromal keratocytes and stromal fibroblasts

GHF Yam, GP Williams, M Setiawan, NZBM Yusoff… - Scientific reports, 2017 - nature.com
Laser refractive surgeries reshape corneal stroma to correct refractive errors, but
unavoidably affect corneal nerves. Slow nerve regeneration and atypical neurite …

Imaging of the corneal subbasal whorl-like nerve plexus: more accurate depiction of the extent of corneal nerve damage in patients with diabetes

T Utsunomiya, T Nagaoka, K Hanada… - … & visual science, 2015 - iovs.arvojournals.org
Purpose: To show that noninvasive in vivo corneal confocal microscopy (IVCM) can make
more accurate imaging of the corneal subbasal nerve plexus possible. This diagnostic …

The neuroregenerative effects of topical decorin on the injured mouse cornea

M Wu, LE Downie, LM Grover, RJA Moakes… - Journal of …, 2020 - Springer
Background The cornea is innervated with a rich supply of sensory nerves that play
important roles in ocular surface health. Any injury or pathology of the corneal nerves …

Recovery of the sub-basal nerve plexus and superficial nerve terminals after corneal epithelial injury in mice

LE Downie, CN Golborne, M Chen, N Ho… - Experimental Eye …, 2018 - Elsevier
Our aim was to compare regeneration of the sub-basal nerve plexus (SBNP) and superficial
nerve terminals (SNT) following corneal epithelial injury. We also sought to compare …

Short-term effects of overnight orthokeratology on corneal sub-basal nerve plexus morphology and corneal sensitivity

M Nombela-Palomo, G Felipe-Marquez… - Eye & Contact …, 2018 - journals.lww.com
Objective: To assess the effects of a short period of orthokeratology (OK) on corneal sub-
basal nerve plexus (SBNP) morphology and corneal sensitivity. Methods: Measurements …