Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …

Checkpoint inhibition immunotherapy has revolutionized cancer treatment, but many
patients show resistance. Here we perform integrative transcriptomic and proteomic …

Simple Summary A bottleneck in oncology is the translation of results from preclinical
models to the clinics. The rate of anticancer drugs that are effective in preclinical studies but …

A pervasive view is that undifferentiated stem cells are alone responsible for generating all
other cells and are the origins of cancer. However, emerging evidence demonstrates fully …

Abstract/outline The field of high content imaging has steadily evolved and expanded
substantially across many industry and academic research institutions since it was first …

Small nucleotide variants in non-coding regions of the genome can alter transcriptional
regulation, leading to changes in gene expression which can activate oncogenic gene …

Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. Traditional
therapeutic approaches such as chemotherapy or radiotherapy have provided only a …

For tumor treatment, the ultimate goal in tumor therapy is to eliminate the primary tumor,
manage potential metastases, and trigger an antitumor immune response, resulting in the …

Distinguishing genomic alterations in cancer-associated genes that have functional impact
on tumor growth and disease progression from the ones that are passengers and confer no …