An unprecedented revolution in medicinal chemistry driven by the progress of biological science
KC Chou - Current topics in medicinal chemistry, 2017 - ingentaconnect.com
The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …
various diseases and extend human beings' life as long as possible. Human being is a …
Pseudo nucleotide composition or PseKNC: an effective formulation for analyzing genomic sequences
With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent
to develop automated methods for analyzing the relationship between the sequences and …
to develop automated methods for analyzing the relationship between the sequences and …
[HTML][HTML] iACP: a sequence-based tool for identifying anticancer peptides
Cancer remains a major killer worldwide. Traditional methods of cancer treatment are
expensive and have some deleterious side effects on normal cells. Fortunately, the …
expensive and have some deleterious side effects on normal cells. Fortunately, the …
iRNA (m6A)-PseDNC: identifying N6-methyladenosine sites using pseudo dinucleotide composition
As a prevalent post-transcriptional modification, N 6-methyladenosine (m 6 A) plays key
roles in a series of biological processes. Although experimental technologies have been …
roles in a series of biological processes. Although experimental technologies have been …
iNuc-PseKNC: a sequence-based predictor for predicting nucleosome positioning in genomes with pseudo k-tuple nucleotide composition
Motivation: Nucleosome positioning participates in many cellular activities and plays
significant roles in regulating cellular processes. With the avalanche of genome sequences …
significant roles in regulating cellular processes. With the avalanche of genome sequences …
[HTML][HTML] Pse-in-One 2.0: an improved package of web servers for generating various modes of pseudo components of DNA, RNA, and protein sequences
B Liu, H Wu, KC Chou - Natural science, 2017 - scirp.org
Pse-in-One 2.0 is a package of web-servers evolved from Pse-in-One (Liu, B., Liu, F., Wang,
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …
PseAAC-General: fast building various modes of general form of Chou's pseudo-amino acid composition for large-scale protein datasets
P Du, S Gu, Y Jiao - International journal of molecular sciences, 2014 - mdpi.com
The general form pseudo-amino acid composition (PseAAC) has been widely used to
represent protein sequences in predicting protein structural and functional attributes. We …
represent protein sequences in predicting protein structural and functional attributes. We …
Identification of real microRNA precursors with a pseudo structure status composition approach
Containing about 22 nucleotides, a micro RNA (abbreviated miRNA) is a small non-coding
RNA molecule, functioning in transcriptional and post-transcriptional regulation of gene …
RNA molecule, functioning in transcriptional and post-transcriptional regulation of gene …
Ictx‐type: a sequence‐based predictor for identifying the types of conotoxins in targeting ion channels
Conotoxins are small disulfide‐rich neurotoxic peptides, which can bind to ion channels with
very high specificity and modulate their activities. Over the last few decades, conotoxins …
very high specificity and modulate their activities. Over the last few decades, conotoxins …
ISS‐PseDNC: Identifying splicing sites using pseudo dinucleotide composition
In eukaryotic genes, exons are generally interrupted by introns. Accurately removing introns
and joining exons together are essential processes in eukaryotic gene expression. With the …
and joining exons together are essential processes in eukaryotic gene expression. With the …