Three decades of genetic research in Alzheimer disease (AD) have substantially broadened
our understanding of the pathogenetic mechanisms leading to neurodegeneration and …

The aetiology of most neurodegenerative disorders is multifactorial and consists of an
interaction between environmental factors and genetic predisposition. Free radicals derived …

There is a dire need to discover new targets for Alzheimer's disease (AD) drug development.
Decreased neuronal glucose metabolism that occurs in AD brain could play a central role in …

Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Microtubule-associated Tau proteins belong to a family of factors that polymerize tubulin
dimers and stabilize microtubules. Tau is strongly expressed in neurons, localized in the …

Alzheimer's disease is an incurable chronic neurodegenerative disorder and the leading
cause of dementia, imposing a growing economic burden upon society. The disease …

L-arginine is a semi-essential amino acid with a number of bioactive metabolites.
Accumulating evidence suggests the implication of altered arginine metabolism in the …

Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …

The only recognized genetic determinant of the common forms of Alzheimer's disease (AD)
is the ɛ4 allele of the apolipoprotein E gene (APOE). To identify new candidate genes, we …

Chronic sleep loss profoundly impacts metabolic health and shortens lifespan, but studies of
the mechanisms involved have focused largely on acute sleep deprivation. 1, 2 To identify …