Astrocytes: dissecting their diverse roles in amyotrophic lateral sclerosis and frontotemporal dementia
CF Valori, C Sulmona, L Brambilla, D Rossi - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons
LS Capano, C Sato, E Ficulle, A Yu, K Horie, JS Kwon… - Cell Stem Cell, 2022 - cell.com
Tau is a microtubule-binding protein expressed in neurons, and the equal ratios between 4-
repeat (4R) and 3-repeat (3R) isoforms are maintained in normal adult brain function …
repeat (4R) and 3-repeat (3R) isoforms are maintained in normal adult brain function …
[HTML][HTML] Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes
KR Bowles, C Pedicone, DA Pugh, LM Oja, FH Sousa… - Cell Reports, 2024 - cell.com
Due to the importance of 4R tau (with four microtubule-binding-repeat domains) in the
pathogenicity of primary tauopathies, it has been challenging to model these diseases in …
pathogenicity of primary tauopathies, it has been challenging to model these diseases in …
[HTML][HTML] Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function
KR Bowles, DA Pugh, C Pedicone, L Oja, SA Weitzman… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Due to the importance of 4R tau in the pathogenicity of primary tauopathies, it has been
challenging to model these diseases in iPSC-derived neurons, which express very low …
challenging to model these diseases in iPSC-derived neurons, which express very low …