The Akt/mechanistic target of rapamycin (mTOR) signaling pathway governs macromolecule
synthesis, cell growth, and metabolism in response to nutrients and growth factors …

The circadian clock temporally organizes cellular physiology throughout the day, allowing
daily environmental changes to be anticipated and potentially harmful physiologic …

The circadian clock coordinates physiology and metabolism. mTOR (mammalian/
mechanistic target of rapamycin) is a major intracellular sensor that integrates nutrient and …

Dysregulation of the activity of the mechanistic target of rapamycin complex 1 (mTORC1) is
commonly linked to aging, cancer, and genetic disorders such as tuberous sclerosis (TS), a …

The circadian clock is a timekeeping system for numerous biological rhythms that contribute
to the regulation of numerous homeostatic processes in humans. Disruption of circadian …

Abstract Circadian (~ 24 h) rhythms in physiology and behavior are evolutionarily conserved
and found in almost all living organisms. The rhythms are endogenously driven by daily …

The mammalian circadian clockwork has evolved as a timing system that allows the daily
environmental changes to be anticipated so that behavior and tissue physiology can be …

Sleep is an evolutionarily conserved and powerful drive, although its complete functions are
still unknown. One possible function of sleep is that it promotes brain development. The …

In mammals, the circadian clock coordinates cell physiological processes including
inflammation. Recent studies suggested a crosstalk between these two pathways. However …

The time of day strongly influences adaptive behaviors like long-term memory, but the
correlating synaptic and molecular mechanisms remain unclear. The circadian clock …