[HTML][HTML] Influence of prenatal drug exposure, maternal inflammation, and parental aging on the development of autism spectrum disorder

A Sato, H Kotajima-Murakami, M Tanaka… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) affects reciprocal social interaction and produces abnormal
repetitive, restrictive behaviors and interests. The diverse causes of ASD are divided into …

[HTML][HTML] Gestational hypoxia in late pregnancy differentially programs subcortical brain maturation in male and female rat offspring

EN Wilson, S Mabry, JL Bradshaw, JJ Gardner… - Biology of sex …, 2022 - Springer
Background Hypoxia is associated with pregnancy complications, such as preeclampsia,
placental abruption, and gestational sleep apnea. Hypoxic insults during gestation can …

[HTML][HTML] Altered offspring neurodevelopment in an L-NAME-induced preeclampsia rat model

N Nakamura, T Ushida, A Onoda, K Ueda… - Frontiers in …, 2023 - frontiersin.org
Introduction To investigate the mechanism underlying the increased risk of subsequent
neurodevelopmental disorders in children born to mothers with preeclampsia, we evaluated …

Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk

SB Gumusoglu, MD Kiel, A Gugel… - …, 2024 - nature.com
Psychiatric and obstetric diseases are growing threats to public health and share high rates
of co-morbidity. G protein-coupled receptor signaling (eg, vasopressin, serotonin) may be a …

Preeclampsia promotes autism in offspring via maternal inflammation and fetal NFκB signaling

X Liu, H Liu, N Gu, J Pei, X Lin… - Life Science …, 2023 - life-science-alliance.org
Preeclampsia (PE) is a risk factor for autism spectrum disorder (ASD) in offspring. However,
the exact mechanisms underlying the impact of PE on progeny ASD are not fully understood …

[HTML][HTML] Neurodevelopmental Disruptions in Children of Preeclamptic Mothers: Pathophysiological Mechanisms and Consequences

A González-Rojas, M Valencia-Narbona - International Journal of …, 2024 - mdpi.com
Preeclampsia (PE) is a multisystem disorder characterized by elevated blood pressure in the
mother, typically occurring after 20 weeks of gestation and posing risks to both maternal and …

Abnormal cerebral microvascular perfusion and reactivity in female offspring of reduced uterine perfusion pressure (RUPP) mice model

E Lara, N Rivera, A González-Bernal… - Journal of Cerebral …, 2022 - journals.sagepub.com
Children born from women with preeclampsia have alterations in cerebral neurovascular
development and a high risk for developing cognitive alterations. Because cerebral blood …

[HTML][HTML] Maternal pre-eclampsia serum increases neurite growth and mitochondrial function through a potential IL-6-dependent mechanism in differentiated SH-SY5Y …

A Barron, S Manna, CJ McElwain, A Musumeci… - Frontiers in …, 2023 - frontiersin.org
Introduction: Pre-eclampsia (PE) is a common and serious hypertensive disorder of
pregnancy, which affects 3%–5% of first-time pregnancies and is a leading cause of …

Preeclampsia as a possible risk factor for memory impairment, anxiety-and depressive-like behavior in offspring

BR Vélez-Godínez, P López-Sánchez… - …, 2024 - Springer
Rationale Preeclampsia is a condition that can affect the health in offspring at adult life. The
effect on several systems has been described, but less is known about its effect on …

[HTML][HTML] Sodium concentrations in municipal drinking water are associated with an increased risk of preeclampsia

DA Thompson, DM Cwiertny, HA Davis, A Grant… - Environmental …, 2022 - Elsevier
Chronic ingestion of excess sodium has been associated with high blood pressure, heart
disease, and stroke. Limited research has suggested a relationship between increased …