Site-specific recombinase systems (Cre-loxP, Flp-FRT, and φC31-att) are transforming both
forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be …

The cerebellum is a pre-eminent model for the study of neurogenesis and circuit assembly.
Increasing interest in the cerebellum as a participant in higher cognitive processes and as a …

Detailed analysis of neuronal network architecture requires the development of new
methods. Here we present strategies to visualize synaptic circuits by genetically labelling …

We describe a method termed MADM (mosaic analysis with double markers) in mice that
allows simultaneous labeling and gene knockout in clones of somatic cells or isolated single …

One of the most powerful tools that the molecular biology revolution has given us is the
ability to turn genes on and off at our discretion. In the mouse, this has been accomplished …

We have utilized an in vivo-inducible genetic-fate-mapping strategy to permanently label
cohorts of Math1-positive cells and their progeny that arise in the rhombic lip of the …

The rhombic lip (RL) is an embryonic proliferative neuroepithelium that generates several
groups of hindbrain neurons. However, the precise boundaries and derivatives of the RL …

The cerebellum is one of the first brain structures to begin to differentiate, yet it is one of the
last to achieve maturity—the cellular organization of the cerebellum continues to change for …

Recent advances in molecular biology have drastically changed our vision on the
development of the nervous system, the cerebellum in particular. After a classical descriptive …

BACKGROUND AND PURPOSE: Because of improved visualization of posterior fossa
structures with MR imaging, cerebellar malformations are recognized with increasing …