Spore formation and germination are essential for the bacterial pathogen Clostridioides
difficile to transmit infection. Despite the importance of these developmental processes to the …

As obligate anaerobes, clostridial pathogens depend on their metabolically dormant, oxygen-
tolerant spore form to transmit disease. However, the molecular mechanisms by which those …

The current classification of the phylum Firmicutes (new name, Bacillota) features eight
distinct classes, six of which include known spore-forming bacteria. In Bacillus subtilis …

Clostridioides (formerly Clostridium) difficile is a leading cause of healthcare-associated
infections. Although considerable progress has been made in the understanding of its …

In the human intestinal pathogen Clostridium difficile, flagella promote adherence to
intestinal epithelial cells. Flagellar gene expression also indirectly impacts production of the …

The gram-positive human pathogen Clostridioides difficile has emerged as the leading
cause of antibiotic-associated diarrhea. However, little is known about the bacterium's …

Clostridioides difficile is a Gram-positive, spore-forming obligate anaerobe and a major
threat to the healthcare system world-wide. Because of its strict anaerobic requirements, the …

A genomic signature for endosporulation includes a gene coding for a protease, YabG,
which in the model organism Bacillus subtilis is involved in assembly of the spore coat. We …

Clostridium difficile, a major human enteropathogen, must cope with foreign DNA invaders
and multiple stress factors inside the host. We have recently provided an experimental …

Clostridioides difficile causes diarrheal diseases mediated in part by the secreted toxins
TcdA and TcdB. C. difficile produces flagella that also contribute to motility and bacterial …