Abstract Bioactive sphingolipids: sphingosine, sphingosine-1-phosphate (S1P), ceramide,
and ceramide-1-phosphate (C1P) are increasingly implicated in cell survival, proliferation …

Mitochondrial dysfunction, a hallmark of aging, has been associated with the onset of aging
phenotypes and age-related diseases. Here, we report that impaired mitochondrial function …

The gradual ageing of the world population has been accompanied by a dramatic increase
in the prevalence of obesity and metabolic diseases, especially type 2 diabetes. The …

Skin plays central roles in systemic physiology, and it undergoes significant functional
changes during aging. Members of the peroxisome proliferator-activated receptor-gamma …

Summary Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while
promoting glycolysis. However, lower glycolysis is compromised in human clear cell renal …

Objective Obesity is a multidimensional condition that is treatable by the restoration of a lean
phenotype; however, some obesity-related outcomes may persist after weight normalization …

Mitochondria play a vital role in non-shivering thermogenesis in both brown and
subcutaneous white adipose tissues (BAT and scWAT, respectively). However, specific …