This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …

Leishmaniasis is a group of vector-borne diseases caused by intracellular protozoan
parasites belonging to the genus Leishmania. Leishmania parasites can employ different …

Thioredoxin reductase (TR) can help pathogens resist oxidative‐burst injury from host
immune cells by maintaining a thioredoxin‐reduction state during NADPH consumption. TR …

The ability of an organism to sense and respond to environmental redox fluctuations relies
on a signaling network that is incompletely understood in apicomplexan parasites such as …

Purposes Evaluate the effect of auranofin on the early and late stages of chronic infection
with Toxoplasma gondii avirulent ME49 strain. Methods Swiss albino mice were orally …

Purposes Evaluate the effect of auranofin on the early and late stages of chronic infection
with Toxoplasma gondii avirulent ME49 strain. Methods Swiss albino mice were orally …

Purposes Evaluate the effect of auranofin on the early and late stages of chronic infection
with Toxoplasma gondii avirulent ME49 strain. Methods Swiss albino mice were orally …

Obligate intracellular pathogens must invade host cells to survive and pose a global health
risk. As such, internalization is a critical life stage and represents an excellent therapeutic …

Aislado por primera vez desde el roedor africano Ctenodactylus gundii en 1908 por Nicolle
C y Manceaux, Toxoplasma gondii es el único miembro del género Toxoplasma (Hunter …

Protein disulfide isomerases (PDIs) ensure that specific substrate proteins are correctly
folded. PDI activity plays an essential role in malaria transmission. Here we provide an …