The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

Transgenerational epigenetic inheritance in mammals remains a debated subject. Here, we
demonstrate that DNA methylation of promoter-associated CpG islands (CGIs) can be …

Maintenance of genome stability requires control over the expression of transposable
elements (TEs), whose activity can have substantial deleterious effects on the host …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

Mammalian male germ-cell development consists of three distinct phases: primordial germ
cell (PGC) development, male germ-cell specification for spermatogonium development …

Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,
respectively. The interest in understanding the various biological functions of DNA and RNA …

Histone modifications are fundamental epigenetic regulators that control many crucial
cellular processes. However, whether these marks can be passed on from mammalian …

Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for
development. We show that the transcriptional program of hPGCs is distinct from that in …

Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …