Chromatin-binding proteins are critical regulators of cell state in haematopoiesis,. Acute
leukaemias driven by rearrangement of the mixed lineage leukaemia 1 gene (KMT2A r) or …

The dysregulation of developmental and stem cell–associated genes is a common
phenomenon during cancer development. Around half of patients with acute myeloid …

The direct targeting of chromatin-associated proteins is increasingly recognized as a
potential therapeutic strategy for the treatment of cancer. In this review, we discuss a …

Acute myeloid leukemia (AML) is a devastating hematologic malignancy with high rates of
relapse, which can, in part, be attributed to the dysregulation of chromatin modifications …

Chromatin regulation involves the selective recruitment of chromatin factors to facilitate DNA
repair, replication and transcription. Here we demonstrate the utility of coupling unbiased …

Acute myeloid leukemia (AML) remains difficult to treat and requires new therapeutic
approaches. Potent inhibitors of the chromatin-associated protein MENIN have recently …

Reactivation of fetal hemoglobin expression by the downregulation of BCL11A is a
promising treatment for β-hemoglobinopathies. A detailed understanding of BCL11A …

Chromosomal translocations involving the mixed-lineage leukemia (MLL) locus generate
potent oncogenic fusion proteins (oncoproteins) that disrupt regulation of developmental …

Acute protein knockdown is a powerful approach to dissecting protein function in dynamic
cellular processes. We previously reported an improved auxin-inducible degron system …

MicroRNAs (miRNAs) play crucial roles in physiological functions and disease, but the
regulation of their nuclear biogenesis remains poorly understood. Here, BioID on Drosha …