Transcriptional regulation is a fundamental molecular mechanism involved in almost every
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …

The circadian clock modulates human physiology. However, the organization of tissue-
specific gene expression rhythms and how these depend on age and sex is not defined in …

We present a major update of the HOCOMOCO collection that consists of patterns
describing DNA binding specificities for human and mouse transcription factors. In this …

Diversity within or between tumours and metastases (known as intra-patient tumour
heterogeneity) that develops during disease progression is a serious hurdle for therapy …

Background Tumor progression is accompanied by dramatic remodeling of the surrounding
extracellular matrix leading to the formation of a tumor-specific ECM, which is often more …

INTRODUCTION Therapies targeted against the tumor microenvironment (TME) represent a
promising approach for treating cancer. This appeal arises in part from the decreased …

Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-
associated fatty liver disease; yet, the mechanisms underlying the progression from the …

Abstract Analysis of gene expression has contributed to a plethora of biological and medical
research studies. Microarrays have been intensively used for the profiling of gene …

The human genome contains more than 4.5 million inserts derived from transposable
elements (TEs), the result of recurrent waves of invasion and internal propagation …

Tumor-specific T cells are frequently exhausted by chronic antigenic stimulation. We here
report on a human antigen-specific ex vivo model to explore new therapeutic options for T …