Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
Signaling via the NFκB system
The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …
development, immune responses, inflammation, and cancer. The NFκB signaling system …
NF-κB and the transcriptional control of inflammation
JP Mitchell, RJ Carmody - International review of cell and molecular …, 2018 - Elsevier
The NF-κB transcription factor was discovered 30 years ago and has since emerged as the
master regulator of inflammation and immune homeostasis. It achieves this status by means …
master regulator of inflammation and immune homeostasis. It achieves this status by means …
The regulation of NF-κB subunits by phosphorylation
F Christian, EL Smith, RJ Carmody - Cells, 2016 - mdpi.com
The NF-κB transcription factor is the master regulator of the inflammatory response and is
essential for the homeostasis of the immune system. NF-κB regulates the transcription of …
essential for the homeostasis of the immune system. NF-κB regulates the transcription of …
Inhibitory feedback control of NF-κB signalling in health and disease
JA Prescott, JP Mitchell, SJ Cook - Biochemical Journal, 2021 - portlandpress.com
Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …
Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
A Kauppinen, T Suuronen, J Ojala, K Kaarniranta… - Cellular signalling, 2013 - Elsevier
Recent studies have indicated that the regulation of innate immunity and energy metabolism
are connected together through an antagonistic crosstalk between NF-κB and SIRT1 …
are connected together through an antagonistic crosstalk between NF-κB and SIRT1 …
Limiting inflammation—the negative regulation of NF-κB and the NLRP3 inflammasome
A properly mounted immune response is indispensable for recognizing and eliminating
danger arising from foreign invaders and tissue trauma. However, the'inflammatory …
danger arising from foreign invaders and tissue trauma. However, the'inflammatory …
Crosstalk in NF-κB signaling pathways
NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis
and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn …
and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn …
The nuclear factor NF-κB pathway in inflammation
T Lawrence - Cold Spring Harbor perspectives in biology, 2009 - cshperspectives.cshlp.org
The nuclear factor NF-κB pathway has long been considered a prototypical proinflammatory
signaling pathway, largely based on the role of NF-κB in the expression of proinflammatory …
signaling pathway, largely based on the role of NF-κB in the expression of proinflammatory …
The IκB kinase complex in NF‐κB regulation and beyond
M Hinz, C Scheidereit - EMBO reports, 2014 - embopress.org
The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed
of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also …
of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also …