Recent advancements in understanding the tumor microenvironment (TME) have
highlighted the critical role of the nervous system in cancer progression. This review …

T lymphocytes (T cells) are an important sub-group of cells in our immune system
responsible for cell-mediated adaptive responses and maintaining immune homeostasis …

Current immunotherapies provide limited benefits against T cell-depleted tumors, calling for
therapeutic innovation. Using multi-omics integration of cancer patient data, we predict a …

The advent of cancer immunotherapy based on PD-1 and CTLA-4 immune checkpoint
blockade (ICB) has revolutionized cancer treatment. However, many cancers do not respond …

This review summarizes emerging evidence that the neuroendocrine system is involved in
the regulation of the tumor immune microenvironment (TIME) to influence cancer …

As the field of cancer neuroscience expands, the strategic targeting of interactions between
neurons, cancer cells and other elements in the tumour microenvironment represents a …

Myeloid-derived suppressor cells (MDSC) are a population of heterogeneous immune cells
that are involved in precancerous conditions and neoplasms. The autonomic nervous …

The Nab-paclitaxel combined with gemcitabine (AG) regimen is the main chemotherapy
regimen for pancreatic cancer, but drug resistance often occurs. Currently, the ability to …

Background Osteosarcoma is the most common malignant primary bone tumor in infants
and adolescents. The lack of understanding of the molecular mechanisms underlying …

In this review, we will summarize current and past findings on the adrenergic regulation of
myeloid cell functions and dynamics, with special emphasis on the pathophysiological …