Recent developments in the cyclization of alkynes and nitrogen compounds for the synthesis of indole derivatives

JSS Neto, G Zeni - Asian Journal of Organic Chemistry, 2021 - Wiley Online Library
This review is intended to highlight the most useful approaches for the synthesis of indole
derivatives (azaindoles, carbazoles, carbolines, indazoles, 3H‐indoles, indolines …

Biological evaluation of indolizine-chalcone hybrids as new anticancer agents

S Park, EH Kim, J Kim, SH Kim, I Kim - European Journal of Medicinal …, 2018 - Elsevier
A new chemical space was explored based on an indolizine-chalcone hybrid, which was
readily accessible by base-mediated aldol condensation of indolizine bearing a 7-acetyl …

Synthesis of Pyrrolo[2,1-a]isoquinolines through Cu-Catalyzed Condensation/Addition/Oxidation/Cyclization Cascade

HL Cui, XH Chen - The Journal of Organic Chemistry, 2022 - ACS Publications
We have developed a copper-catalyzed synthesis of pyrrolo [2, 1-a] isoquinolines with
terminal alkynes, aldehydes, and tetrahydroisoquinolines. A variety of pyrrolo [2, 1-a] …

Rhodium(III)-Catalyzed Intramolecular Annulation and Aromatization for the Synthesis of Pyrrolo[1,2-a]quinolines

Y Hu, Y Jia, Z Tuo, W Zhou - Organic Letters, 2023 - ACS Publications
A rhodium (III)-catalyzed protocol for the synthesis of pyrrolo [1, 2-a] quinolines through
intramolecular annulation of o-alkynyl amino aromatic ketones and subsequent …

Iron-catalyzed indolizine synthesis from pyridines, diazo compounds, and alkynes

T Douglas, A Pordea, J Dowden - Organic letters, 2017 - ACS Publications
The iron (III)-catalyzed synthesis of indolizines from commercially available alkyne, pyridine,
and diazo precursors is reported. This mild, expedient method is tolerant of various solvents …

Transition-metal-Free regioselective cross-coupling: controlled synthesis of mono-or dithiolation indolizines

B Li, Z Chen, H Cao, H Zhao - Organic letters, 2018 - ACS Publications
An efficient transition-metal-free regioselective C–H/S–H cross-coupling of indolizines with
thiols has been developed for the first time to describe a workable route to indolizine …

Synthesis of benzoindolizines through 1, 5-electrocyclization/oxidation cascades

SW Liu, YJ Gao, Y Shi, L Zhou, X Tang… - The Journal of Organic …, 2018 - ACS Publications
This study presents a convenient synthesis of pyrrolo [1, 2-a] quinolines and pyrrolo [2, 1-a]
isoquinolines with simple quinolines or isoquinolines and Morita–Baylis–Hillman …

Palladium catalyzed synthesis of indolizines via the carbonylative coupling of bromopyridines, imines and alkynes

SA Roy, J Zgheib, C Zhou, BA Arndtsen - Chemical Science, 2021 - pubs.rsc.org
We report herein the development of a palladium-catalyzed, multicomponent synthesis of
indolizines. The reaction proceeds via the carbonylative formation of a high energy …

Diversity‐Oriented Metal‐Free Synthesis of Nitrogen‐Containing Heterocycles Using Atropaldehyde Acetals as a Dual C3/C2‐Synthon

S Chen, B You, T Zhang, M Li, Y Gu - ChemSusChem, 2022 - Wiley Online Library
A highly efficient and elegant diversity‐oriented reaction paradigm employing atropaldehyde
acetals as new dual C2/C3 synthons was developed under metal‐free conditions using …

Pyrroloquinolines, imidazoquinolines, and pyrroloquinazolines with a bridgehead nitrogen

F Dumitrascu, F Georgescu, E Georgescu… - Advances in Heterocyclic …, 2019 - Elsevier
This chapter presents recent advances in the chemistry of heterocyclic ring systems with a
nitrogen bridgehead including pyrrolo [1, 2-a] quinoline, imidazo [1, 2-a] quinoline, imidazo …