Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …

Cancer stem cells (CSCs) are a small subpopulation in cancer, have been proposed to be
cancer-initiating cells, and have been shown to be responsible for chemotherapy resistance …

Cell fusion has been used for many different purposes, including generation of hybridomas
and reprogramming of somatic cells. The fusion step is the key event in initiation of these …

Generation of induced pluripotent stem cells (iPSCs) is a process whose mechanistic
underpinnings are only beginning to emerge. Here, we applied in-depth quantitative …

Liver cancers, including hepatocellular carcinomas (HCCs), cholangiocarcinomas (CCs),
and fibrolamellar HCCs (FL‐HCCs) are among the most common cancers worldwide and …

The diagnosis of testicular germ cell tumors (GCTs) sometimes can be challenging without
ancillary markers. Here we performed an immunohistochemical study of a novel stem cell …

Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-
renewal, pluripotency, and somatic cell reprogramming. However, limited information is …

Embryonic stem cells have potential utility in regenerative medicine because of their
pluripotent characteristics. Sall4, a zinc-finger transcription factor, is expressed very early in …

There is a growing body of evidence supporting that cancer cells share many similarities
with embryonic stem cells (ESCs). For example, aggressive cancers and ESCs share a …

Ovarian primitive germ cell tumors (GCTs) are uncommon tumors and sometimes pose
diagnostic challenges. Among them, yolk sac tumor (YST) poses the greatest diagnostic …