Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics

F Gong, N Yang, X Wang, Q Zhao, Q Chen, Z Liu… - Nano Today, 2020 - Elsevier
The design and development of tumor microenvironment (TME)-responsive intelligent
nanoplatforms have attracted increasing interest to enhance the therapeutic effects of drugs …

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Y Dai, C Xu, X Sun, X Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared
with normal tissue, the tumour microenvironment has some unique properties, such as …

[HTML][HTML] Calcium carbonate vaterite particles for drug delivery: Advances and challenges

DB Trushina, TN Borodina, S Belyakov… - Materials Today …, 2022 - Elsevier
The recent successful application of lipid-based nanoparticles as delivery vehicles in COVID-
19 vaccines demonstrated the superior potential of nanoparticle-based technology for …

Synthesis of Hollow Biomineralized CaCO3–Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin …

Z Dong, L Feng, Y Hao, M Chen, M Gao… - Journal of the …, 2018 - ACS Publications
The development of activatable nanoplatforms to simultaneously improve diagnostic and
therapeutic performances while reducing side effects is highly attractive for precision cancer …

Nanomedicine for tumor microenvironment modulation and cancer treatment enhancement

J Liu, Q Chen, L Feng, Z Liu - Nano Today, 2018 - Elsevier
Cancer, one of major threats to the human health, possesses intricate structure and
constituents distinctive from normal organs and tissues. It has been well recognized that the …

Tumor Microenvironment Modulating CaCO3‐Based Colloidosomal Microreactors Can Generally Reinforce Cancer Immunotherapy

Z Dong, Y Liu, C Wang, Y Hao, Q Fan… - Advanced …, 2024 - Wiley Online Library
Tumor hypoxia and acidity, two general features of solid tumors, are known to have negative
effect on cancer immunotherapy by directly causing dysfunction of effector immune cells and …

Programmed Release of Dihydroartemisinin for Synergistic Cancer Therapy Using a CaCO3 Mineralized Metal–Organic Framework

X Wan, H Zhong, W Pan, Y Li, Y Chen… - Angewandte Chemie …, 2019 - Wiley Online Library
Dihydroartemisinin (DHA) has attracted increasing attention as an anticancer agent.
However, using DHA to treat cancer usually depends on the synergistic effects of exogenous …

Calcium-based biomaterials for diagnosis, treatment, and theranostics

C Qi, J Lin, LH Fu, P Huang - Chemical Society Reviews, 2018 - pubs.rsc.org
Calcium-based (CaXs) biomaterials including calcium phosphates, calcium carbonates,
calcium silicate and calcium fluoride have been widely utilized in the biomedical field owing …

CaCO3 nanoparticles as an ultra-sensitive tumor-pH-responsive nanoplatform enabling real-time drug release monitoring and cancer combination therapy

Z Dong, L Feng, W Zhu, X Sun, M Gao, H Zhao, Y Chao… - Biomaterials, 2016 - Elsevier
The exploration of stimuli-responsive nano-theranostics provides powerful tools for
simultaneously enhancing the accuracy and efficiency of cancer therapies. Herein, we …

Nanoenabled modulation of acidic tumor microenvironment reverses anergy of infiltrating T cells and potentiates anti-PD-1 therapy

YX Zhang, YY Zhao, J Shen, X Sun, YI Liu, H Liu… - Nano …, 2019 - ACS Publications
While tumor-infiltrating cytotoxic T lymphocytes play a critical role in controlling tumor
development, they are generally impotent in an acidic tumor microenvironment. Systemic …