Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors

I Jurado-Martín, M Sainz-Mejías… - International journal of …, 2021 - mdpi.com
Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF)
contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its …

Progress in alternative strategies to combat antimicrobial resistance: Focus on antibiotics

J Murugaiyan, PA Kumar, GS Rao, K Iskandar… - Antibiotics, 2022 - mdpi.com
Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR),
continues to evolve and spread beyond all boundaries. As a result, infectious diseases have …

[HTML][HTML] The role of vaccines in combatting antimicrobial resistance

F Micoli, F Bagnoli, R Rappuoli, D Serruto - Nature Reviews …, 2021 - nature.com
The use of antibiotics has enabled the successful treatment of bacterial infections, saving the
lives and improving the health of many patients worldwide. However, the emergence and …

Pseudomonas aeruginosa: Recent Advances in Vaccine Development

M Killough, AM Rodgers, RJ Ingram - Vaccines, 2022 - mdpi.com
Pseudomonas aeruginosa is an important opportunistic human pathogen. Using its arsenal
of virulence factors and its intrinsic ability to adapt to new environments, P. aeruginosa …

The potential role of vaccines in preventing antimicrobial resistance (AMR): An update and future perspectives

V Costanzo, GN Roviello - Vaccines, 2023 - mdpi.com
In the modern era, the consumption of antibiotics represents a revolutionary weapon against
several infectious diseases, contributing to the saving of millions of lives worldwide …

The promising potential of reverse vaccinology-based next-generation vaccine development over conventional vaccines against antibiotic-resistant bacteria

K Khalid, CL Poh - Vaccines, 2023 - mdpi.com
The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR)
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …

What Is New in the Anti–Pseudomonas aeruginosa Clinical Development Pipeline Since the 2017 WHO Alert?

S Reig, A Le Gouellec, S Bleves - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
The spread of antibiotic-resistant bacteria poses a substantial threat to morbidity and
mortality worldwide. Carbapenem-resistant Pseudomonas aeruginosa (CRPA) are …

Immunotherapies against human bacterial and fungal infectious diseases: A review

H Qadri, AH Shah, M Alkhanani… - Frontiers in …, 2023 - pmc.ncbi.nlm.nih.gov
Nations' ongoing struggles with a number of novel and reemerging infectious diseases,
including the ongoing global health issue, the SARS-Co-V2 (severe acute respiratory …

Immunoinformatics-Aided Design and Evaluation of a Potential Multi-Epitope Vaccine against Klebsiella Pneumoniae

HA Dar, T Zaheer, M Shehroz, N Ullah, K Naz… - Vaccines, 2019 - mdpi.com
Klebsiella pneumoniae is an opportunistic gram-negative bacterium that causes nosocomial
infection in healthcare settings. Despite the high morbidity and mortality rate associated with …

[HTML][HTML] Emerging therapies against infections with Pseudomonas aeruginosa

B Tümmler - F1000Research, 2019 - ncbi.nlm.nih.gov
Infections with Pseudomonas aeruginosa have been marked with the highest priority for
surveillance and epidemiological research on the basis of parameters such as incidence …