Integration of epigenetic mechanisms into non-genotoxic carcinogenicity hazard assessment: Focus on DNA methylation and histone modifications
D Desaulniers, P Vasseur, A Jacobs… - International Journal of …, 2021 - mdpi.com
Epigenetics involves a series of mechanisms that entail histone and DNA covalent
modifications and non-coding RNAs, and that collectively contribute to programing cell …
modifications and non-coding RNAs, and that collectively contribute to programing cell …
A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling
JM Yeakley, PJ Shepard, DE Goyena… - PloS one, 2017 - journals.plos.org
The use of gene expression signatures to classify compounds, identify efficacy or toxicity,
and differentiate close analogs relies on the sensitivity of the method to identify modulated …
and differentiate close analogs relies on the sensitivity of the method to identify modulated …
A Tox21 approach to altered epigenetic landscapes: assessing epigenetic toxicity pathways leading to altered gene expression and oncogenic transformation in vitro
CL Parfett, D Desaulniers - International journal of molecular sciences, 2017 - mdpi.com
An emerging vision for toxicity testing in the 21st century foresees in vitro assays assuming
the leading role in testing for chemical hazards, including testing for carcinogenicity. Toxicity …
the leading role in testing for chemical hazards, including testing for carcinogenicity. Toxicity …
Sensitive and specific miRNA detection method using SplintR Ligase
J Jin, S Vaud, AM Zhelkovsky, J Posfai… - Nucleic acids …, 2016 - academic.oup.com
We describe a simple, specific and sensitive microRNA (miRNA) detection method that
utilizes Chlorella virus DNA ligase (SplintR® Ligase). This two-step method involves ligation …
utilizes Chlorella virus DNA ligase (SplintR® Ligase). This two-step method involves ligation …
A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives
FA Grimm, Y Iwata, O Sirenko, GA Chappell… - Green chemistry, 2016 - pubs.rsc.org
Comparative assessment of potential human health impacts is a critical step in evaluating
both chemical alternatives and existing products on the market. Most alternatives …
both chemical alternatives and existing products on the market. Most alternatives …
Assessing long-distance RNA sequence connectivity via RNA-templated DNA–DNA ligation
Many RNAs, including pre-mRNAs and long non-coding RNAs, can be thousands of
nucleotides long and undergo complex post-transcriptional processing. Multiple sites of …
nucleotides long and undergo complex post-transcriptional processing. Multiple sites of …
Simple isothermal strategy for multiplexed, rapid, sensitive, and accurate miRNA detection
MicroRNAs (miRNA) are potential biomarkers. Current preferred miRNA detection methods
rely on various PCR-based approaches. Although effective, such methods are typically …
rely on various PCR-based approaches. Although effective, such methods are typically …
Attenuators
JM Yeakley, B Seligmann, J McComb - US Patent 9,957,550, 2018 - Google Patents
US9957550B2 - Attenuators - Google Patents US9957550B2 - Attenuators - Google Patents
Attenuators Download PDF Info Publication number US9957550B2 US9957550B2 US14/480,525 …
Attenuators Download PDF Info Publication number US9957550B2 US9957550B2 US14/480,525 …
[HTML][HTML] Analytical validation of androgen receptor splice variant 7 detection in a clinical laboratory improvement amendments (CLIA) laboratory setting
PM Lokhandwala, SL Riel, L Haley, C Lu… - The Journal of Molecular …, 2017 - Elsevier
Patients with castration-resistant prostate cancer (CRPC) often are treated with drugs that
target the androgen receptor (AR) ligand-binding domain. Constitutively active AR splice …
target the androgen receptor (AR) ligand-binding domain. Constitutively active AR splice …
Moving toward integrating gene expression profiling into high-throughput testing: A gene expression biomarker accurately predicts estrogen receptor α modulation in …
Microarray profiling of chemical-induced effects is being increasingly used in medium-and
high-throughput formats. Computational methods are described here to identify molecular …
high-throughput formats. Computational methods are described here to identify molecular …