The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

Retinal diseases constitute a genetically and phenotypically diverse group of clinical
conditions leading to vision impairment or blindness with limited treatment options …

Numerous protocols have been described for producing neural retina from human
pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids …

Age-related macular degeneration (AMD) causes severe visual impairment due in part to
age-dependent impairment of retinal pigment epithelium (RPE). It has been suggested that …

Cultures of growth-arrested feeder cells have been used for years to promote cell
proliferation, particularly with low-density inocula. Basically, feeder cells consist in a layer of …

Next-generation and Sanger sequencing were combined to identify disease-causing
USH2A mutations in an adult patient with autosomal recessive RP. Induced pluripotent stem …

Photoreceptor degeneration due to retinitis pigmentosa (RP) is a primary cause of inherited
retinal blindness. Photoreceptor cell-replacement may hold the potential for repair in a …

Loss of photoreceptors due to retinal degeneration is a major cause of blindness in the
developed world. While no effective treatment is currently available, cell replacement …

Immunologically-matched, induced pluripotent stem cell (iPSC)-derived photoreceptor
precursor cells have the potential to restore vision to patients with retinal degenerative …

The endoplasmic reticulum (ER) is the primary intracellular organelle responsible for protein
and lipid biosynthesis, protein folding and trafficking, calcium homeostasis, and several …