In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of
the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck …

Simple Summary Tyrosine phosphorylation is the first biochemical event that occurs after
TCR engagement, which is crucial for T-cell development, activation and differentiation …

T cell–antigen receptor (TCR) signaling requires the sequential activities of the kinases Lck
and Zap70. Upon TCR stimulation, Lck phosphorylates the TCR, thus leading to the …

The cell-mediated immune response constitutes a robust host defense mechanism to
eliminate pathogens and oncogenic cells. T cells play a central role in such a defense …

LAG3 disrupts the TCR signal by local acidification | Nature Immunology Skip to main content
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Although signal transduction by immunoreceptors such as the T cell antigen receptor (TCR),
B cell antigen receptor (BCR), and Fc receptors uses the same schematic and similar …

Immune cells transduce environmental stimuli into responses essential for host health via
complex signaling cascades. T cells, in particular, leverage their unique T cell receptors …

The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3
complex. Phosphorylation of some of its tyrosines generates recruitment sites for other …

Intracellular signaling through the T cell receptor (TCR) is essential for T cell development
and function. Proper TCR signaling requires the sequential activities of Lck and ZAP-70 …

The primary activating receptor for T cells is the T cell receptor (TCR), which is stimulated
upon binding to an antigen/MHC complex. TCR activation results in the induction of …