Circadian rhythms in neurodegenerative disorders

M Nassan, A Videnovic - Nature Reviews Neurology, 2022 - nature.com
Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

Association between circadian rhythms and neurodegenerative diseases

Y Leng, ES Musiek, K Hu, FP Cappuccio… - The Lancet …, 2019 - thelancet.com
Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however,
circadian rhythm disruptions are more severe in people with age-related neurodegenerative …

Circadian disruption and sleep disorders in neurodegeneration

Y Shen, Q Lv, W Xie, S Gong, S Zhuang, J Liu… - Translational …, 2023 - Springer
Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative
diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional …

Circadian rhythm and disease: Relationship, new insights, and future perspectives

AR Neves, T Albuquerque, T Quintela… - Journal of cellular …, 2022 - Wiley Online Library
The circadian system is responsible for internal functions and regulation of the organism
according to environmental cues (zeitgebers). Circadian rhythm dysregulation or …

Sleep and circadian rhythms in Parkinson's disease and preclinical models

J Hunt, EJ Coulson, R Rajnarayanan, H Oster… - Molecular …, 2022 - Springer
The use of animals as models of human physiology is, and has been for many years, an
indispensable tool for understanding the mechanisms of human disease. In Parkinson's …

Alzheimer's retinopathy: seeing disease in the eyes

N Mirzaei, H Shi, M Oviatt, J Doustar… - Frontiers in …, 2020 - frontiersin.org
The neurosensory retina emerges as a prominent site of Alzheimer's disease (AD)
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …

Neurodegeneration and the circadian clock

S Hood, S Amir - Frontiers in aging neuroscience, 2017 - frontiersin.org
Despite varied etiologies and symptoms, several neurodegenerative diseases—specifically,
Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HDs)—share the common …

[HTML][HTML] Alzheimer's disease stage identification using deep learning models

S Bringas, S Salomón, R Duque, C Lage… - Journal of Biomedical …, 2020 - Elsevier
Objective The aim of this research is to identify the stage of Alzheimer's Disease (AD)
patients through the use of mobility data and deep learning models. This process facilitates …

Functionalised penetrating peptide-chondroitin sulphate‑gold nanoparticles: Synthesis, characterization, and applications as an anti-Alzheimer's disease drug

Y Feng, X Li, D Ji, J Tian, Q Peng, Y Shen… - International Journal of …, 2023 - Elsevier
The purpose of this study was to construct a transmembrane peptide-chondroitin sulphate‑
gold nanoparticle (TAT-CS@ Au) delivery system and investigate its activity as an anti …

Circadian and sleep dysfunctions in neurodegenerative disorders—An update

K Fifel, A Videnovic - Frontiers in Neuroscience, 2021 - frontiersin.org
Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in
patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered …